BHF Centre of Research Excellence
Robin P Choudhury MA, DM, FACC
Divisional Research Themes
- Cardiovascular Science
- Imaging
Cardiovascular subthemes
Group Members
- Mr Asim Akhtar
- Dr Erica Dall' Armelina
- Dr Janet Digby
- Dr Andrew Jefferson
- Dr Alistair Lindsay
- Dr Kulveer Mankia
- Dr Gosia Malgorzata
- Dr Martina A McAteer
- Dr Neil Rupareila
- Dr Rohan Wijesurendra
Former Group Members
- Mr Tom Bannister
- Dr Ilias Kylintireas
- Mr Vincent Lam
- Dr Justin Lee
- Dr Constantin von zur Muhlen
Collaborators
- Dr Daniel Anthony, Department of Pharmacology, Oxford
- Prof Keith Channon, Department of Cardiovascular Medicine, Oxford
- Prof Ben Davis, Department of Chemistry, Oxford
- Dr David Greaves, Sir William Dunn School of Pathology, Oxford
- Prof Peter Jezzard, FMRIB
- Prof Stefan Neubauer, Department of Cardiovascular Medicine, Oxford
- Dr Matthew Robson, Department of Cardiovascular Medicine, Oxford
- Dr Jürgen Schneider, Department of Cardiovascular Medicine, Oxford
- Dr Nicola Sibson, Radiation Oncology and Biology, Oxford
- Prof Kathryn Wood, Nuffield Department of Surgery, Oxford
Selected Publications
- Digby Janet E, McNeill Eileen, Dyar Oliver J, Lam Vincent, Greaves David R, and Choudhury Robin P (2010) Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin. Atherosclerosis, 209(1):89-95.
- Lee Justin MS, Robson Matthew D, Yu Ly-Mee, Shirodaria Cheerag C, Cunnington Colin, Kylintireas Ilias, Digby Janet E, Bannister Thomas, Handa Ashok, Wiesmann Frank, Durrington Paul N, Channon Keith M, Neubauer Stefan, and Choudhury Robin P (2009) Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: a randomized, placebo-controlled, magnetic resonance imaging study. J Am Coll Cardiol, 54(19):1787-94.
- Lee Justin MS, Wiesmann Frank, Shirodaria Cheerag, Leeson Paul, Petersen Steffen E, Francis Jane M, Jackson Clare E, Robson Matthew D, Neubauer Stefan, Channon Keith M, and Choudhury Robin P (2008) Early changes in arterial structure and function following statin initiation: quantification by magnetic resonance imaging. Atherosclerosis, 197(2):951-8.
- Lindsay Alistair C and Choudhury Robin P (2008) Form to function: current and future roles for atherosclerosis imaging in drug development. Nat Rev Drug Discov, 7(6):517-29.
- McAteer Martina A, Schneider Jurgen E, Ali Ziad A, Warrick Nicholas, Bursill Christina A, von zur Muhlen Constantin, Greaves David R, Neubauer Stefan, Channon Keith M, and Choudhury Robin P (2008) Magnetic resonance imaging of endothelial adhesion molecules in mouse atherosclerosis using dual-targeted microparticles of iron oxide. Arterioscler Thromb Vasc Biol, 28(1):77-83.
| Web | Personal Website |
|---|---|
| robin.choudhury@cardiov.ox.ac.uk | |
| Tel | 01865 234664 |
| Fax | 01865 234667 |
| PA | Ms Eunice Berry |
| Email (PA) | eunice.berry@ndm.ox.ac.uk |
| Contact address | Department of Cardiovascular Medicine, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom |
| Department | Department of Cardiovascular Medicine |
| College | Balliol College |
Prof Robin Choudhury
Work in this group is focused in three areas:
(1) Development and application of IMAGING TECHNIQUES TO CHARACTERIZE ATHEROSCLEROSIS AND VASCULAR DISEASE. The aim is to obtain tools that will (a) provide insights into the pathophysiology of atherosclerosis and its complications; (b) obtain earlier and more refined diagnosis; and (c) quantify the response to therapeutic interventions. 
Clinical Science: Using ‘multi-modal’ vascular MRI in the Oxford Clinical Magnetic Resonance Centre (OCMR) we measure endothelial function, large vessel physiology and atherosclerosis burden in an integrated examination. In this way, it has been possible to characterise disease and quantify response to specific treatments rapidly and in small numbers of patients (Lee et al. Atherosclerosis, 2009).
Basic science: We have developed a new class of ligand-conjugated micro-particles of iron oxide for molecular imaging. Using MRI at high field strength (7-11T) we are working to develop imaging probes that target specific molecules and through collaboration (below) have applied these to illuminate pathology in diverse models of disease that include: atherosclerosis and thrombosis, stroke, ischaemia, reperfusion injury and multiple sclerosis (McAteer et al ATVB 2008, Nature Medicine 2007).
(2) Development and application of IMAGING TECHNIQUES TO CHARACTERISE 'UPSTREAM' AND 'DOWNSTREAM pathology in acute vascular syndromes. The Oxford Acute Vascular Imaging Centre (below) provides unique opportunities to study the 'upstream' cause and 'downstream' consequences of acute myocardial infarction and stroke. AVIC is equipped with a 3T Siemens Verio MR scanner in functional continuity with a fully equipped invasive angiography suite.
(3) Interventions to retard progression and induce REGRESSION OF ATHEROSCLEROSIS. Clinical Science: We have recently completed follow-up of a randomized, double blind, placebo controlled trial examining the effects of HDL-cholesterol elevation with nicotinic acid on atherosclerosis burden and vascular function, demonstrating regression of atherosclerosis in patients treated with niacin (vs placebo). (Lee et al. J Am Coll Cardiol 2009).
Basic science: Investigation of the role of inflammation in the progression of atherosclerosis and in interventions that reduce inflammation (Digby et al Atherosclerosis 2010).
