News & Events

Benefits associated with intensive lowering of LDL cholesterol

Posted 11/09/2014

CTSU researchers led the SEARCH trial which looked at intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily. The results, published in The Lancet, provide clear evidence that lowering of LDL cholesterol concentrations lowers the risk of major vascular events and that ...

Temporal pixel multiplexing - a new imaging modality

Posted 11/09/2014

Newly developed technology enables simultaneous high-speed, high resolution imaging Method development efforts in Peter Kohl's Cardiac Mechano-Electric Feedback Group have given rise to a Nature Methods paper by Gil Bub et al. that describes how one can combine still and video photography in one ...

Persistant nNOS overexpression mediated by a lenti viral vector modulates cardiac neurotransmission

Posted 11/09/2014

A recent paper from Prof Paterson's team has shown that site specific targeting of a lenti viral vector with nNOS overexpression into cardiac autonomic neurons can reduce sympathetic transmission and enhance cholinergic transmission over many months. This approach may provide a new tool to target ...

Aspirin in primary prevention: overall benefit is uncertain

Posted 11/09/2014

CTSU researchers and colleagues have just published results in The Lancet demonstrating that whilst taking aspirin is beneficial in preventing heart attacks and strokes among people with established cardiovascular disease (secondary prevention), its benefits don’t clearly outweigh the risks of ...

NAADP mobilizes calcium from acidic organelles through two-pore channels

Posted 11/09/2014

Prof Antony Galione and Dr John Parrington, together with their international collaborators have just published results in Nature demonstrating that a novel family of proteins, two pore channels, act as the target receptor for NAADP on lysosomes, mediating calcium release. Previous studies by ...

A new mechanism for the Frank-Starling Law?

A new mechanism for the Frank-Starling Law?

Posted 11/09/2014

A possible role for microtubules in modulating cardiac ryanodine receptor function. A recent Circulation Research front-page article by the team of Dr Peter Kohl has revealed that axial stretch of intact rat cardiomyoctyes acutely and transiently increases sarcoplasmic reticulum Ca2+ spark rate ...

BMI is a strong predictor of overall mortality

Posted 11/09/2014

CTSU researchers are part of the Propsective Studies Collaboration which has just published results in The Lancet demonstrating that body-mass index is in itself a strong predictor of overall mortality. Collaborative analyses of 57 prospective studies, which included nearly 900,000 adults, has ...

2008 RAE Results

Posted 11/09/2014

The University of Oxford received the highest quality rating of any cardiovascular medicine return in the country in the 2008 RAE results announced in December. In the 2008 RAE, cardiovascular research in Oxford was returned in three categories: Cardiovascular Medicine, Pre-Clinical and Human ...