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Both CC and CXC-class chemokines drive inflammatory disease. Tick salivary chemokine-binding proteins (CKBPs), or evasins, specifically bind subsets of CC- or CXC-chemokines, and could precisely target disease-relevant chemokines. Here we have used yeast surface display to identify two tick evasins: a CC-CKBP, P1243 from Amblyomma americanum and a CXC-CKBP, P1156 from Ixodes ricinus. P1243 binds 11 CC-chemokines with Kd 

Original publication

DOI

10.1038/s41598-018-24568-9

Type

Journal article

Journal

Scientific reports

Publication Date

20/04/2018

Volume

8

Pages

6333 - 6333

Addresses

RDM Division of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom.