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Receptor binding studies of novel anti-inflammatory peptides

  • 1 December 2009 to 30 November 2010
  • Awards: Pump-priming Awards

This BHF CRE pump priming award allowed us to do receptor binding studies of a novel chemerin-derived peptide that exhibited anti-inflammatory activity in animal models. Subsequent to this pump-priming award  a US start up pharma company explored the potential of chemerin-derived peptides in Phase 1 clinical trials for psoriasis.

Publications linked to this award:

  1. Hart R, Greaves DR. Chemerin contributes to inflammation by promoting macrophage adhesion to VCAM-1 and fibronectin through clustering of VLA-4 and VLA-5. J Immunol. 2010 Sep 15;185(6):3728-39. doi: 10.4049/jimmunol.0902154. Epub 2010 Aug 18.
  2. Cash JL, Christian AR, Greaves DR. Chemerin peptides promote phagocytosis in a ChemR23- and Syk-dependent manner. J Immunol. 2010 May 1;184(9):5315-24. doi: 10.4049/jimmunol.0903378.