Yvonne Couch
Oxford BHF CRE Basic Science Intermediate Transition Fellow
- Start date: 1st August 2024
- End date: 31st July 2026
- BHF CRE mentors: Prof. Damian Tyler & Prof. Heidi Johansen-Berg
Project title: The longer-term metabolic consequences of stroke
Research summary
Traditional PET imaging of metabolic processes fails to give us the full picture of metabolic processing in tissue. The brain is an extremely metabolically active organ and understanding what happens to metabolism in the CNS, especially in injuries such as stroke, and in diseases such as dementia, is the long-term goal for this research.

This project will use models of stroke to determine changes in metabolic activity in the acute and chronic phases after injury. By using a combination of male and female and young and old animals, we hope to more accurately represent the patient population post-stroke.
I will continue to work with experts in post-stroke recovery and imaging (Profs. Johansen-Berg and Tyler) in order to make the most of this transitional fellowship with the ultimate aim of turning into a larger project studying metabolism from bench to bedside in post-stroke dementia in the future.
Recent publications
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Lesion level and severity acutely influence metabolomic profiles in spinal cord injury.
Journal article
Yates AG. et al, (2025), J Neuropathol Exp Neurol
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Rapamycin Treatment Reduces Brain Pericyte Constriction in Ischemic Stroke.
Journal article
Beard DJ. et al, (2024), Transl Stroke Res
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Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.
Journal article
Welsh JA. et al, (2024), J Extracell Vesicles, 13
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Rapamycin Treatment Reduces Brain Pericyte Constriction in Ischemic Stroke
Preprint
Beard D. et al, (2024)
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The effects of fasting on acute ischemic infarcts in the rat.
Journal article
Schneider AM. et al, (2024), PLoS One, 19