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Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematologic parameters. Here we show a significant impact of HMIP variability on several types of peripheral blood cells: erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans.

Original publication

DOI

10.1182/blood-2007-05-093419

Type

Journal article

Journal

Blood

Publication Date

15/11/2007

Volume

110

Pages

3624 - 3626

Keywords

Blood Cell Count, Blood Platelets, Chromosomes, Human, Pair 6, DNA, Intergenic, Erythrocytes, Female, Genes, myb, Humans, Male, Monocytes, Peptide Elongation Factor 1, Polymorphism, Single Nucleotide