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We recently identified the RNA-binding protein serine/arginine-rich splicing factor 3 (SRSF3) as a putative candidate that may regulate epicardial cell activation, migration and cell fate. With the pump priming award, we imported floxed Srsf3 mice and generated pilot data from epicardium-specific knockout lines. Subsequent research funded by a DPhil studentship and project grant award (both from BHF) revealed novel mechanisms by which epicardial cell proliferation, migration and cell fate are regulated during development. Ongoing research now seeks to understand how these processes contribute to the repair response in the infarcted heart and how they may be harnessed for optimal regeneration.