Resolving Inflammation and Fibrosis
(Inflammatory cells, fibroblasts)
- determine how inflammation impacts on stem/progenitor cell proliferation, incorporation at the injury site and on subsequent differentiation;
- elucidate how immune cells contribute to wound healing and fibrosis (scarring);
- identify novel molecular targets which underpin inflammatory cell recruitment. retention and polarisation for subsequent therapeutic manipulation to modulate scarring and promote regeneration.