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Establishing a cellular model to investigate Filamin C-related cardiomyopathy

  • 1 January 2016 to 31 December 2017
  • Awards: Pump-priming Awards

As part of this award we have established the usage of genome-edited induced pluripotent stem cell cardiomyocytes to model cardiomyopathies in vitro. This will help us to understand disease mechanisms better and also reduce the usage of animal models in our research.

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Publication linked to this award:

1. Ehsan, M., Jiang, H., L.Thomson, K. and Gehmlich, K. (2017). When signalling goes wrong: pathogenic variants in structural and signalling proteins causing cardiomyopathies. Journal of Muscle Research and Cell Motility, 38(3-4), pp.303-316.