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Oxford BHF CRE Research Themes

The Oxford BHF CRE has four core Research Themes and includes over 70 individual Principal Investigators and their research groups across the University. The four selected focal areas for the BHF CRE are Big Data, Human Genetics, Target Discovery and Development & Regeneration which are categorised by scientific approach rather than disease entity, and are designed to facilitate cross-fertilisation.

Themes

Big Data

Led by Prof Hugh Watkins, to span inherited diseases (gene discovery, phenotyping, disease mechanisms and clinical application of genetic testing) through to post-GWAS functional analyses, including model organism and cell biology approaches aiming to extract biological insight from genetically validated mechanisms.

Human Genetics

Led by Prof Keith Channon, will incorporate the best of our hypothesis driven, disease mechanism research where efforts are specifically targeted to discovery of tractable targets and medicinal chemistry approaches (existing partnerships with Chemistry and the Target Discovery Institute and new links with the Structural Genomics Consortium and the Interdisciplinary Science building).

Target Discovery

Led by Prof Paul Riley, to understand the underlying biology of cardiovascular development, develop novel models of congenital heart disease and to explore ways in which developmental processes can be harnessed to promote heart regeneration and repair.

Development & Regeneration