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New target identified to develop treatment for Abdominal Aortic Aneurysm
CRM Publication
30 March 2021
A new study from the Smart group has shed light on a key regulatory step in the initiation and progression of Abdominal Aortic Aneurysm by revealing the protective role of a previously little known small protein.
Travels with Vignesh
CRM General
9 February 2021
Vignesh Murugesan, a Postdoctoral Researcher in Department of Physiology, Anatomy & Genetics (DPAG), describes how he found his way from the large metropolitan town of Chennai in India to studying regenerative medicine here in Oxford, via an 8 year stint in Sweden.
Paul Riley appointed Director of Oxford’s Institute of Developmental and Regenerative Medicine
CRM General
11 October 2020
Professor Paul Riley will lead the scientific vision of the first institute of its kind in the world to physically merge the disciplines of developmental biology and regenerative medicine in a common goal to treat some of the world’s most prolific diseases.
HCQ with antibiotics to treat COVID-19 could be dangerous for the heart
CRM General
26 May 2020
DPAG researchers have collaborated on an international study that demonstrates a detailed mechanistic understanding of how the anti-malaria drug, Hydroxychloroquine, combined with antibiotics, can cause adverse cardiac side-effects in COVID-19 patients. This gives weight to US Federal advice against using this combined treatment.
DPAG and RDM researchers set to reveal the role of inflammatory cells in heart repair
CRM Research
29 April 2020
DPAG's Associate Professor Mathilda Mommersteeg and Professor Paul Riley, in collaboration with Professor Robin Choudhury from the Radcliffe Department of Medicine, will perform single cell analysis of inflammation during heart regeneration with a grant from the Chan Zuckerberg Initiative.
Heart scarring run by Runx1 gene
CRM General
27 April 2020
New collaborative research from the Mommersteeg Group and MRC WIMM researchers shows that a protein called Runx1 plays a significant role in the formation of the cardiac scar that forms after the heart is injured, a scar that is known to inhibit heart regeneration. In the zebrafish, a freshwater fish known to be able to fully regenerate its heart after damage, they show that the absence of Runx1 results in enhanced regeneration. This indicates a potential new therapeutic target for heart repair.
Study uncovers molecular 'first responder' that triggers heart-attack causing plaques
CRE CRM Research
6 February 2020
Potential strategy identified to improve blood vessel growth after heart attack
CRE CRM General
22 July 2019
A collaborative paper from the De Val and Smart Groups has established multiple regulatory pathways responsible for the formation of blood vessels in the developing heart. In doing so they have identified a crucial pathway that is repressed in the adult heart after injury, which may hold the key to a new and improved strategy for repair.
From bugs to drugs
CRE CRM General
16 July 2019
Decoding the pharmacological goldmine in tick saliva.
Collaborating BHF CRM groups develop a platelet producing bone marrow bioreactor
CRM Publication Research
4 September 2018