New research from the Heather Group has shown that in type 2 diabetes an overload of lipids reduces the heart\u2019s ability to generate energy during a heart attack, decreasing chances of recovery.
In animal models, iron deficient mothers have a greatly increased risk of having offspring with congenital heart disease (CHD). The risk of CHD can be greatly reduced if the mother is given iron supplements very early in pregnancy. Additionally, embryos from a mouse model of Down Syndrome were particularly vulnerable to the effects of maternal iron deficiency, leading to a higher risk of developing severe heart defects.
Professor Watkins and his team have found a new type of genetic change in the DNA of people with hypertrophic cardiomyopathy (HCM) - a silent killer amongst families that can cause sudden death in young people due to the thickening of the heart muscle.
The earliest known progenitor of the outermost layer of the heart has been characterised for the first time and linked to the development of other critical cell types in the developing heart in a new paper from the Srinivas group led by BHF Immediate Fellow Dr Richard Tyser.
Professor Sir Rory Collins, Head of the Nuffield Department of Population Health, and Principal Investigator and Chief Executive of UK Biobank, has been awarded the Medical Research Council (MRC) Millennium Medal 2020, the MRC\u2019s most prestigious personal award.
New research led by Oxford BHF CRE Intermediate Transition Fellow Dr Kerstin Timm shows that a recently developed imaging technique pioneered by the Tyler Group can detect early metabolic changes in the heart caused by a commonly used chemotherapy drug, which is known to increase risk of heart failure in cancer survivors.
Associate Professor Neil Herring has been awarded a Senior Clinical Research Fellowship and a Project grant from the British Heart Foundation to further critical research into the mechanisms behind heart attacks and heart failure and potential drugs to combat them. Given the 50% reduction in research investment this year from the BHF due to the impact of COVID-19, Prof Herring is to be congratulated on these awards.
A hormone which helps regulate bone mass is also produced by the heart and could help treat people with a dangerous heart rhythm disorder, according to a new study published in the journal Nature.
Researchers at the Nuffield Department of Population Health, in collaboration with other researchers, have published new findings that identify a combination of factors that put some patients at higher risk of myopathy.
DPAG's Associate Professor Mathilda Mommersteeg and Professor Paul Riley, in collaboration with Professor Robin Choudhury from the Radcliffe Department of Medicine, will perform single cell analysis of inflammation during heart regeneration with a grant from the Chan Zuckerberg Initiative.
DPAG's Dr Jakub Tomek and Professor Blanca Rodriguez's Computational Cardiovascular Science Team have developed a new computer model that recreates the electrical activity of the ventricles in a human heart. In doing so, they have uncovered and resolved theoretical inconsistencies that have been present in almost all models of the heart from the last 25 years and created a new human heart model that could enable more basic, translational and clinical research into a range of heart diseases and potentially accelerate the development of new therapies.
An immune cell is shown for the first time to be involved in creating the scar that repairs the heart after damage. The Riley Group study was funded by the British Heart Foundation and led by BHF CRE Intermediate Transition Research Fellow Dr Filipa Sim\u00f5es.
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\n \n \n\n\n ![\"Scientific](\"https://www.cardioscience.ox.ac.uk/images/news/a-mechano-receptor-that-induces-cellular-plasticity-and-cardiovascular-disease/responsive_image?ratio=r16x9&v=1626871274000&scale=w760\")
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\n \n \n\n\n ![\"Frontal](\"https://www.cardioscience.ox.ac.uk/images/news/earliest-origins-of-the-forming-heart-identified/responsive_image?ratio=r16x9&v=1625783322000&scale=w760\")
\n \n \n\n\n ![\"Professor](\"https://www.cardioscience.ox.ac.uk/images/news/professor-sir-rory-collins-awarded-the-mrc-millennium-medal-2020-1/responsive_image?ratio=r16x9&v=1671199491000&scale=w760\")
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\n \n \n\n\n ![\"Schematic](\"https://www.cardioscience.ox.ac.uk/images/news/study-uncovers-molecular-first-responder-that-triggers-heart-attack-causing-plaques/responsive_image?ratio=r16x9&v=1625783310000&scale=w760\")
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