Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
Wang H., Noordam R., Cade BE., Schwander K., Winkler TW., Lee J., Sung YJ., Bentley AR., Manning AK., Aschard H., Kilpeläinen TO., Ilkov M., Brown MR., Horimoto AR., Richard M., Bartz TM., Vojinovic D., Lim E., Nierenberg JL., Liu Y., Chitrala K., Rankinen T., Musani SK., Franceschini N., Rauramaa R., Alver M., Zee PC., Harris SE., van der Most PJ., Nolte IM., Munroe PB., Palmer ND., Kühnel B., Weiss S., Wen W., Hall KA., Lyytikäinen L-P., O'Connell J., Eiriksdottir G., Launer LJ., de Vries PS., Arking DE., Chen H., Boerwinkle E., Krieger JE., Schreiner PJ., Sidney S., Shikany JM., Rice K., Chen Y-DI., Gharib SA., Bis JC., Luik AI., Ikram MA., Uitterlinden AG., Amin N., Xu H., Levy D., He J., Lohman KK., Zonderman AB., Rice TK., Sims M., Wilson G., Sofer T., Rich SS., Palmas W., Yao J., Guo X., Rotter JI., Biermasz NR., Mook-Kanamori DO., Martin LW., Barac A., Wallace RB., Gottlieb DJ., Komulainen P., Heikkinen S., Mägi R., Milani L., Metspalu A., Starr JM., Milaneschi Y., Waken RJ., Gao C., Waldenberger M., Peters A., Strauch K., Meitinger T., Roenneberg T., Völker U., Dörr M., Shu X-O., Mukherjee S., Hillman DR., Kähönen M., Wagenknecht LE., Gieger C., Grabe HJ., Zheng W., Palmer LJ., Lehtimäki T., Gudnason V., Morrison AC., Pereira AC., Fornage M., Psaty BM., van Duijn CM., Liu C-T., Kelly TN., Evans MK., Bouchard C., Fox ER., Kooperberg C., Zhu X., Lakka TA., Esko T., North KE., Deary IJ., Snieder H., Penninx BWJH., Gauderman WJ., Rao DC., Redline S., van Heemst D.
Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups in two stages using 2 degree of freedom (df) joint test followed by 1df test of interaction effects. Primary multi-ancestry analysis in 62,969 individuals in stage 1 identified three novel gene by sleep interactions that were replicated in an additional 59,296 individuals in stage 2 (stage 1 + 2 Pjoint