The emergence of endo-lysosomes as ubiquitous Ca2+ stores with their unique cohort of channels has resulted in their being implicated in a growing number of processes in an ever-increasing number of cell types. The architectural and regulatory constraints of these acidic Ca2+ stores distinguishes them from other larger Ca2+ sources such as the ER and influx across the plasma membrane. In view of recent advances in the understanding of the modes of operation, we discuss phagocytosis as a template for how endo-lysosomal Ca2+ signals (generated via TPC and TRPML channels) can be integrated in multiple sophisticated ways into biological processes. Phagocytosis illustrates how different endo-lysosomal Ca2+ signals drive different phases of a process, and how these can be altered by disease or infection.
Biochim Biophys Acta Mol Cell Res
Calcium, Lysosome, Macrophage, NAADP, Phagocytosis, TPC, TRPML, Animals, Calcium, Calcium Channels, Calcium Signaling, Cell Membrane, Endosomes, Humans, Lysosomes, NADP, Phagocytosis, Phagosomes, Transient Receptor Potential Channels