Tousoulis D., Fountoulakis P., Oikonomou E., Antoniades C., Siasos G., Tsalamandris S., Georgiopoulos G., Pallantza Z., Pavlou E., Milliou A., Assimakopoulos MN., Barmparesos N., Giannarakis I., Siamata P., Kaski JC.

BACKGROUND: Diesel exhaust fumes represent one of the most common toxic pollutants. The prolonged effects of acute exposure to this pollutant on inflammatory status and vascular properties are unknown. METHODS: During a 2-h session, 40 healthy subjects were exposed to diesel exhaust fumes and/or filtered air. Endothelial function was assessed with flow mediated dilation, arterial stiffness with pulse wave velocity and reflected waves with augmentation index. C-reactive protein, fibrinogen, protein C levels and protein S activity were also measured. Standard deviation of normal to normal R-R intervals (SDNN) was used to assess heart rate variability. Measurements were assessed before exposure and 2 and 24 h after diesel exposure. RESULTS: Compared with filtered air, exposure to diesel exhaust fumes decreased flow mediated dilation and increased pulse wave velocity and augmentation index up to 24 h after the exposure (p

Acute exposure to diesel affects inflammation and vascular function.

Tousoulis D., Fountoulakis P., Oikonomou E., Antoniades C., Siasos G., Tsalamandris S., Georgiopoulos G., Pallantza Z., Pavlou E., Milliou A., Assimakopoulos MN., Barmparesos N., Giannarakis I., Siamata P., Kaski JC.

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