Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Amino acid analyses reveal that JMJD6-catalysed hydroxylation of RNA-splicing regulatory protein fragments occurs to give hydroxylysine products with 5S stereochemistry. This contrasts with collagen lysyl hydroxylases, which give 5R-hydroxylated products. The work suggests that more than one subfamily of lysyl hydroxylases has evolved and illustrates the importance of stereochemical assignments in proteomic analyses.

Original publication

DOI

10.1002/cbic.201000641

Type

Journal article

Journal

Chembiochem

Publication Date

07/03/2011

Volume

12

Pages

531 - 534

Keywords

Animals, Catalysis, Humans, Hydroxylysine, Jumonji Domain-Containing Histone Demethylases, Ketoglutaric Acids, Magnetic Resonance Spectroscopy, Molecular Structure, Oxidation-Reduction, Oxygenases, Stereoisomerism