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Hypoxia-inducible factors are the universal cellular oxygen-sensitive transcription factors that activate a number of hypoxia responsive genes, some of which are responsible for protective cellular functions. During organ donation, allografts are exposed to significant periods of hypoxia and ischemia. Exploiting this pathway during donor management and organ preservation could prevent and reduce allograft injury and improve the outcomes of organ transplantation. We review the evidence on this pathway in organ preservation, drawing on experimental studies on donor management and ischemia reperfusion injury focusing on kidney, liver, cardiac and lung transplantation. We review the major technical and experimental challenges in exploring this pathway and suggest potential future avenues for research.

Original publication




Journal article


Am J Transplant

Publication Date





1481 - 1487


HIF, hypoxia, ischemia, ischemia reperfusion injury, transplant, Humans, Hypoxia, Hypoxia-Inducible Factor 1, Organ Preservation, Organ Transplantation, Reperfusion Injury, Tissue and Organ Procurement