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Spatial-temporal regulation of bone morphogenetic protein (BMP) and Wnt activity is essential for normal cardiovascular development, and altered activity of these growth factors causes maldevelopment of the cardiac outflow tract and great arteries. In the present study, we show that SOST, a Dan family member reported to antagonize BMP and Wnt activity, is expressed within the medial vessel wall of the great arteries containing smooth muscle cells. The ascending aorta, aortic arch, brachiocephalic artery, common carotids, and pulmonary trunk were all associated with SOST expressing smooth muscle cells, while the heart itself, including the valves, and more distal arteries, that is, pulmonary arteries, subclavian arteries, and descending aorta, were negative. SOST was expressed from embryonic day 15.5 up to the neonatal period. SOST expression, however, did not correspond with inhibition of Smad-dependent BMP activity or beta-catenin-dependent Wnt activity in the great arteries. Activity of both signaling pathways was already down-regulated before induction of SOST expression.

Original publication

DOI

10.1002/dvdy.21054

Type

Journal article

Journal

Dev Dyn

Publication Date

02/2007

Volume

236

Pages

606 - 612

Keywords

Animals, Arteries, Bone Morphogenetic Proteins, Cardiovascular System, Gene Expression Regulation, Developmental, Genetic Markers, Glycoproteins, In Situ Hybridization, Mice, Muscle, Smooth, Signal Transduction, Wnt Proteins