Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A retrospective case-control study was carried out on 80 patients with sporadic frontotemporal dementia and 124 age, sex, and surrogate informant matched controls with respect to various medical and environmental risk factors. Head trauma was associated with an odds ratio of 3.3 (95% confidence interval (CI), 1.3 to 8.1). Although recall bias may play a role, the frontal lobes are known to be especially vulnerable to even mild head trauma. Thyroid disease was associated with a 2.5 times increased risk of frontotemporal dementia (95% CI, 0.9 to 7.9), which was not statistically significant (p = 0.09) owing to limited power. As altered thyroid hormone status has been observed before in frontotemporal dementia, future studies will be important to confirm this observation.

Original publication

DOI

10.1136/jnnp.74.11.1574

Type

Journal article

Journal

J Neurol Neurosurg Psychiatry

Publication Date

11/2003

Volume

74

Pages

1574 - 1576

Keywords

Aged, Case-Control Studies, Craniocerebral Trauma, Dementia, Environment, Female, Frontal Lobe, Humans, Male, Middle Aged, Odds Ratio, Retrospective Studies, Risk Factors, Temporal Lobe, Thyroid Diseases