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Found 16241 matches for
Development & Regeneration
Led by Prof Paul Riley, to understand the underlying biology of cardiovascular development, develop novel models of congenital heart disease and to explore ways in which developmental processes can be harnessed to promote heart regeneration and repair.
Big Data
Led by Prof Sir Rory Collins, incorporates population health sciences and new developments in Oxford’s Big Data Institute with contributions in image analysis, bioengineering, genetic and biomarker approaches in complex traits.
Human Genetics
Led by Prof Hugh Watkins, to span inherited diseases (gene discovery, phenotyping, disease mechanisms and clinical application of genetic testing) through to post-GWAS functional analyses, including model organism and cell biology approaches aiming to extract biological insight from genetically validated mechanisms.
Target Discovery
Led by Prof Keith Channon, will incorporate the best of our hypothesis driven, disease mechanism research where efforts are specifically targeted to discovery of tractable targets and medicinal chemistry approaches (existing partnerships with Chemistry and the Target Discovery Institute and new links with the Structural Genomics Consortium and the Interdisciplinary Science building).
Genetics and Inherited Diseases
Aim: to continue to discover rare, large-effect, genetic variants with which to dissect heart muscle disease and cardiac development, and to uncover susceptibility variants to implicate new processes in vascular disease.
Myocardial Biology
This theme covers the two major areas of work outlined below.
Cardiac Development and Regeneration
Research on normal heart development, mechanisms underlying congenital heart disease and the potential for applying developmental processes to adult cardiovascular repair.
Cellular Signalling
Employing a computational strategy to translate basic science to personalised application.
Cardiovascular Pharmacology
Aim: to focus expertise in drug discovery and pharmacology on the cardiovascular system through synergistic interactions between chemists, pharmacologists, cardiovascular scientists and computational biologists.
Imaging
The cross-cutting theme of imaging has an important integrating role across the CRE programme, with physicists and bioengineers working alongside biomedical researchers.
Large-scale Randomised Evidence
Reliable assessment of the treatment and prevention of cardiovascular disease
Large-scale Observational Epidemiology
Reliable assessment of the main determinants of cardiovascular disease