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New study enables identification of people at particular risk of rare, but serious, muscle-related side effect of statin therapy

CRE Publication Research

Researchers at the Nuffield Department of Population Health, in collaboration with other researchers, have published new findings that identify a combination of factors that put some patients at higher risk of myopathy.

About 5000 heart attack sufferers in England missed out on hospital treatment due to the pandemic

CRE General

The number of admissions to hospital with heart attacks fell by 35% by the end of March.

HCQ with antibiotics to treat COVID-19 could be dangerous for the heart

CRM General

DPAG researchers have collaborated on an international study that demonstrates a detailed mechanistic understanding of how the anti-malaria drug, Hydroxychloroquine, combined with antibiotics, can cause adverse cardiac side-effects in COVID-19 patients. This gives weight to US Federal advice against using this combined treatment.

DPAG and RDM researchers set to reveal the role of inflammatory cells in heart repair

CRM Research

DPAG's Associate Professor Mathilda Mommersteeg and Professor Paul Riley, in collaboration with Professor Robin Choudhury from the Radcliffe Department of Medicine, will perform single cell analysis of inflammation during heart regeneration with a grant from the Chan Zuckerberg Initiative.

Heart scarring run by Runx1 gene

CRM General

New collaborative research from the Mommersteeg Group and MRC WIMM researchers shows that a protein called Runx1 plays a significant role in the formation of the cardiac scar that forms after the heart is injured, a scar that is known to inhibit heart regeneration. In the zebrafish, a freshwater fish known to be able to fully regenerate its heart after damage, they show that the absence of Runx1 results in enhanced regeneration. This indicates a potential new therapeutic target for heart repair.

New human heart model set to boost future cardiac research and therapies

CRE Research

DPAG's Dr Jakub Tomek and Professor Blanca Rodriguez's Computational Cardiovascular Science Team have developed a new computer model that recreates the electrical activity of the ventricles in a human heart. In doing so, they have uncovered and resolved theoretical inconsistencies that have been present in almost all models of the heart from the last 25 years and created a new human heart model that could enable more basic, translational and clinical research into a range of heart diseases and potentially accelerate the development of new therapies.

New target identified for repairing the heart after heart attack

CRE Research

An immune cell is shown for the first time to be involved in creating the scar that repairs the heart after damage. The Riley Group study was funded by the British Heart Foundation and led by BHF CRE Intermediate Transition Research Fellow Dr Filipa Simões.

New heart disease drug to be made available to NHS patients through ground-breaking collaboration

CRE General

Up to 30,000 lives could be saved over the next decade thanks to a proposed pioneering government collaboration with pharmaceutical company Novartis to tackle heart disease – a leading cause of death in the UK.

BHF Associate Medical Director awarded MBE in New Year Honours list

Professor Jeremy Pearson, the BHF’s longest serving Associate Medical Director, has been awarded an MBE in the Queen’s New Year Honours list for services to medical research.

New target identified to help prevent dangerous heart rhythms after heart attack

CRE General

For many years, we have been using beta-blockers to neutralise a specific stress hormone and prevent dangerous heart rhythms following a heart attack. However, a new study led by Associate Professor Neil Herring and published in the European Heart Journal has uncovered evidence for an additional stress hormone acting as a key trigger for dangerous heart rhythms that is not currently targeted by these drugs.

BHF appoints Dr Charmaine Griffiths as new Chief Executive

Dr Charmaine Griffiths will be the new Chief Executive of the BHF from February 2020.

Manuela Zaccolo honoured by the Royal Society of Biology

CRE General

Congratulations are in order to Professor Manuela Zaccolo on being elected Fellow of the Royal Society of Biology.

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