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The emergence of endo-lysosomes as ubiquitous Ca2+ stores with their unique cohort of channels has resulted in their being implicated in a growing number of processes in an ever-increasing number of cell types. The architectural and regulatory constraints of these acidic Ca2+ stores distinguishes them from other larger Ca2+ sources such as the ER and influx across the plasma membrane. In view of recent advances in the understanding of the modes of operation, we discuss phagocytosis as a template for how endo-lysosomal Ca2+ signals (generated via TPC and TRPML channels) can be integrated in multiple sophisticated ways into biological processes. Phagocytosis illustrates how different endo-lysosomal Ca2+ signals drive different phases of a process, and how these can be altered by disease or infection.

Original publication

DOI

10.1016/j.bbamcr.2021.119040

Type

Journal article

Journal

Biochim Biophys Acta Mol Cell Res

Publication Date

06/2021

Volume

1868

Keywords

Calcium, Lysosome, Macrophage, NAADP, Phagocytosis, TPC, TRPML