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Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin secretory capacity in the setting of insulin resistance. We conducted meta-analyses of genome-wide association results for fasting proinsulin from 16 European-ancestry studies in 45,861 individuals. We found 36 independent signals at 30 loci (p value 

Original publication

DOI

10.1016/j.ajhg.2023.01.002

Type

Journal article

Journal

Am J Hum Genet

Publication Date

02/02/2023

Volume

110

Pages

284 - 299

Keywords

GWAS, colocalization, conditional, eQTL, enhancer, fine-mapping, meta-analysis, proinsulin, signal, type 2 diabetes, Humans, Proinsulin, Diabetes Mellitus, Type 2, Genome-Wide Association Study, Insulin, Glucose, Transcription Factors, Homeodomain Proteins