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A complex population of non-coding RNAs is present in higher organisms. These RNAs have a multitude of functions and execute control over gene expression through various, often poorly understood, mechanisms. At present, the identification and analysis of functional regulatory RNAs and disparate ribonucleoprotein complexes remain an experimental challenge for biologists. They require specially designed approaches and techniques in genomics and RNA biochemistry. Developments in technologies based on mass spectrometry could offer sensitive and efficient solutions to analysis of the sequence, structure, modification and composition of RNA.

Original publication

DOI

10.1016/j.tibs.2006.01.004

Type

Journal article

Journal

Trends Biochem Sci

Publication Date

03/2006

Volume

31

Pages

173 - 181

Keywords

Animals, Base Sequence, Humans, Mass Spectrometry, Nucleic Acid Conformation, RNA, RNA Processing, Post-Transcriptional