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MOTIVATION: For many classes of disease the same genetic risk variants underly many related phenotypes or disease subtypes. Multinomial logistic regression provides an attractive framework to analyze multi-category phenotypes, and explore the genetic relationships between these phenotype categories. We introduce Trinculo, a program that implements a wide range of multinomial analyses in a single fast package that is designed to be easy to use by users of standard genome-wide association study software. AVAILABILITY AND IMPLEMENTATION: An open source C implementation, with code and binaries for Linux and Mac OSX, is available for download at SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. CONTACT:

Original publication




Journal article



Publication Date





1898 - 1900


Bayes Theorem, Genome-Wide Association Study, Humans, Logistic Models, Phenotype, Software