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Juxtaposition of the endoplasmic reticulum with mitochondria facilitates Ca(2+) fluxes between the organelles. However, the molecular basis of interorganellar tethering remains unknown. A recent report has identified a fundamental role for the dynamin-related mitofusins in the tethering mechanism, thereby ensuring rapid and high fidelity Ca(2+) signalling between the organelles.

Original publication

DOI

10.1016/j.cub.2009.01.012

Type

Journal article

Journal

Curr Biol

Publication Date

10/03/2009

Volume

19

Pages

R200 - R203

Keywords

Animals, Calcium, Calcium Signaling, Charcot-Marie-Tooth Disease, Dynamins, Endoplasmic Reticulum, GTP Phosphohydrolases, Humans, Membrane Proteins, Mitochondria, Mitochondrial Proteins