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Self-assembling proteins, the basis for a broad range of biological scaffolds, are challenging to study using most structural biology approaches. Here we show that mass spectrometry (MS) in combination with MD simulations captures structural features of short-lived oligomeric intermediates in spider silk formation, providing direct insights into its complex assembly process.

Original publication

DOI

10.1039/c7cc00307b

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

16/03/2017

Volume

53

Pages

3319 - 3322