Genome-wide meta-analysis identifies new susceptibility loci for migraine.
Anttila V., Winsvold BS., Gormley P., Kurth T., Bettella F., McMahon G., Kallela M., Malik R., de Vries B., Terwindt G., Medland SE., Todt U., McArdle WL., Quaye L., Koiranen M., Ikram MA., Lehtimäki T., Stam AH., Ligthart L., Wedenoja J., Dunham I., Neale BM., Palta P., Hamalainen E., Schürks M., Rose LM., Buring JE., Ridker PM., Steinberg S., Stefansson H., Jakobsson F., Lawlor DA., Evans DM., Ring SM., Färkkilä M., Artto V., Kaunisto MA., Freilinger T., Schoenen J., Frants RR., Pelzer N., Weller CM., Zielman R., Heath AC., Madden PAF., Montgomery GW., Martin NG., Borck G., Göbel H., Heinze A., Heinze-Kuhn K., Williams FMK., Hartikainen A-L., Pouta A., van den Ende J., Uitterlinden AG., Hofman A., Amin N., Hottenga J-J., Vink JM., Heikkilä K., Alexander M., Muller-Myhsok B., Schreiber S., Meitinger T., Wichmann HE., Aromaa A., Eriksson JG., Traynor B., Trabzuni D., North American Brain Expression Consortium None., UK Brain Expression Consortium None., Rossin E., Lage K., Jacobs SBR., Gibbs JR., Birney E., Kaprio J., Penninx BW., Boomsma DI., van Duijn C., Raitakari O., Jarvelin M-R., Zwart J-A., Cherkas L., Strachan DP., Kubisch C., Ferrari MD., van den Maagdenberg AMJM., Dichgans M., Wessman M., Smith GD., Stefansson K., Daly MJ., Nyholt DR., Chasman D., Palotie A.
Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.