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The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. The findings of the Rotterdam Study have been presented in close to a 1,000 research articles and reports (see This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.

Original publication




Journal article


Eur J Epidemiol

Publication Date





553 - 572


Aged, Cardiovascular Diseases, Chronic Disease, Cohort Studies, Endocrine System Diseases, Eye Diseases, Female, Genetic Research, Humans, Liver Diseases, Male, Mental Disorders, Middle Aged, Nervous System Diseases, Netherlands, Pharmacoepidemiology, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Research Design