Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Evangelou E., Warren HR., Mosen-Ansorena D., Mifsud B., Pazoki R., Gao H., Ntritsos G., Dimou N., Cabrera CP., Karaman I., Ng FL., Evangelou M., Witkowska K., Tzanis E., Hellwege JN., Giri A., Velez Edwards DR., Sun YV., Cho K., Gaziano JM., Wilson PWF., Tsao PS., Kovesdy CP., Esko T., Mägi R., Milani L., Almgren P., Boutin T., Debette S., Ding J., Giulianini F., Holliday EG., Jackson AU., Li-Gao R., Lin W-Y., Luan J., Mangino M., Oldmeadow C., Prins BP., Qian Y., Sargurupremraj M., Shah N., Surendran P., Thériault S., Verweij N., Willems SM., Zhao J-H., Amouyel P., Connell J., de Mutsert R., Doney ASF., Farrall M., Menni C., Morris AD., Noordam R., Paré G., Poulter NR., Shields DC., Stanton A., Thom S., Abecasis G., Amin N., Arking DE., Ayers KL., Barbieri CM., Batini C., Bis JC., Blake T., Bochud M., Boehnke M., Boerwinkle E., Boomsma DI., Bottinger EP., Braund PS., Brumat M., Campbell A., Campbell H., Chakravarti A., Chambers JC., Chauhan G., Ciullo M., Cocca M., Collins F., Cordell HJ., Davies G., de Borst MH., de Geus EJ., Deary IJ., Deelen J., Del Greco M F., Demirkale CY., Dörr M., Ehret GB., Elosua R., Enroth S., Erzurumluoglu AM., Ferreira T., Frånberg M., Franco OH., Gandin I., Gasparini P., Giedraitis V., Gieger C., Girotto G., Goel A., Gow AJ., Gudnason V., Guo X., Gyllensten U., Hamsten A., Harris TB., Harris SE., Hartman CA., Havulinna AS., Hicks AA., Hofer E., Hofman A., Hottenga J-J., Huffman JE., Hwang S-J., Ingelsson E., James A., Jansen R., Jarvelin M-R., Joehanes R., Johansson Å., Johnson AD., Joshi PK., Jousilahti P., Jukema JW., Jula A., Kähönen M., Kathiresan S., Keavney BD., Khaw K-T., Knekt P., Knight J., Kolcic I., Kooner JS., Koskinen S., Kristiansson K., Kutalik Z., Laan M., Larson M., Launer LJ., Lehne B., Lehtimäki T., Liewald DCM., Lin L., Lind L., Lindgren CM., Liu Y., Loos RJF., Lopez LM., Lu Y., Lyytikäinen L-P., Mahajan A., Mamasoula C., Marrugat J., Marten J., Milaneschi Y., Morgan A., Morris AP., Morrison AC., Munson PJ., Nalls MA., Nandakumar P., Nelson CP., Niiranen T., Nolte IM., Nutile T., Oldehinkel AJ., Oostra BA., O'Reilly PF., Org E., Padmanabhan S., Palmas W., Palotie A., Pattie A., Penninx BWJH., Perola M., Peters A., Polasek O., Pramstaller PP., Nguyen QT., Raitakari OT., Ren M., Rettig R., Rice K., Ridker PM., Ried JS., Riese H., Ripatti S., Robino A., Rose LM., Rotter JI., Rudan I., Ruggiero D., Saba Y., Sala CF., Salomaa V., Samani NJ., Sarin A-P., Schmidt R., Schmidt H., Shrine N., Siscovick D., Smith AV., Snieder H., Sõber S., Sorice R., Starr JM., Stott DJ., Strachan DP., Strawbridge RJ., Sundström J., Swertz MA., Taylor KD., Teumer A., Tobin MD., Tomaszewski M., Toniolo D., Traglia M., Trompet S., Tuomilehto J., Tzourio C., Uitterlinden AG., Vaez A., van der Most PJ., van Duijn CM., Vergnaud A-C., Verwoert GC., Vitart V., Völker U., Vollenweider P., Vuckovic D., Watkins H., Wild SH., Willemsen G., Wilson JF., Wright AF., Yao J., Zemunik T., Zhang W., Attia JR., Butterworth AS., Chasman DI., Conen D., Cucca F., Danesh J., Hayward C., Howson JMM., Laakso M., Lakatta EG., Langenberg C., Melander O., Mook-Kanamori DO., Palmer CNA., Risch L., Scott RA., Scott RJ., Sever P., Spector TD., van der Harst P., Wareham NJ., Zeggini E., Levy D., Munroe PB., Newton-Cheh C., Brown MJ., Metspalu A., Hung AM., O'Donnell CJ., Edwards TL., Psaty BM., Tzoulaki I., Barnes MR., Wain LV., Elliott P., Caulfield MJ., Million Veteran Program None.
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.