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The APOE genotype is involved in atherosclerosis, and atherosclerosis increases the risk of dementia, in particular among carriers of the APOE-epsilon4 allele. We studied, in a population-based setting (244 dementia cases; 1,002 nondemented controls), whether APOE is associated with dementia through atherosclerosis. As neither adjusting nor stratification for atherosclerosis altered the association of APOE with dementia, our study suggests that atherosclerosis is not an intermediate factor.

Original publication

DOI

10.1212/wnl.53.7.1593

Type

Journal article

Journal

Neurology

Publication Date

22/10/1999

Volume

53

Pages

1593 - 1595

Keywords

Aged, Alleles, Apolipoproteins E, Arteriosclerosis, Dementia, Female, Genotype, Humans, Male, Reference Values