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An intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1), that is located at a well established Alzheimer's disease (AD) locus on chromosome 9q22, was recently associated with increased risk for late-onset AD. We analyzed this polymorphism in two independent AD samples consisting of patients with an onset age 70 years or less, but did not observe statistically significant association. Our study does not support a major role for this UBQLN1 polymorphism in AD patients with an earlier onset of disease.

Original publication

DOI

10.1016/j.neulet.2005.08.064

Type

Journal article

Journal

Neurosci Lett

Publication Date

09/01/2006

Volume

392

Pages

72 - 74

Keywords

Age of Onset, Aged, Alzheimer Disease, Carrier Proteins, Case-Control Studies, Cell Cycle Proteins, Chromosomes, Human, Pair 9, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic