Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Medical risk factors for Creutzfeldt-Jakob disease (CJD) were analyzed in a prospective ongoing case-control study based on European CJD surveillance. Detailed data on past and recent medical history were analyzed in 405 cases and controls matched by sex, age, and hospital. Data were correlated with polymorphism at codon 129 of the prion protein gene. Our analysis did not support a number of previously reported associations and failed to identify any common medical risk factor for CJD. Although not statistically significant, brain surgery was associated with an increased risk of CJD. A detailed medical history should be obtained in every suspected CJD case in order to identify iatrogenic sources of CJD.

Type

Journal article

Journal

J Clin Epidemiol

Publication Date

07/2000

Volume

53

Pages

747 - 754

Keywords

Adult, Aged, Case-Control Studies, Creutzfeldt-Jakob Syndrome, Electromyography, Europe, Humans, Middle Aged, Neurosurgical Procedures, Odds Ratio, Polymorphism, Genetic, Population Surveillance, Prions, Risk Factors