Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.

Original publication

DOI

10.1002/ana.10106

Type

Journal article

Journal

Ann Neurol

Publication Date

02/2002

Volume

51

Pages

253 - 256

Keywords

Adult, Age of Onset, Chromosomes, Human, Pair 1, Family Health, Female, Humans, Ligases, Lod Score, Male, Middle Aged, Parkinsonian Disorders, Pedigree, Ubiquitin-Protein Ligases