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Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.

Type

Journal article

Journal

Ann Neurol

Publication Date

02/2002

Volume

51

Pages

253 - 256

Keywords

Adult, Age of Onset, Chromosomes, Human, Pair 1, Family Health, Female, Humans, Ligases, Lod Score, Male, Middle Aged, Parkinsonian Disorders, Pedigree, Ubiquitin-Protein Ligases