The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study.
Slooter AJC., Cruts M., Hofman A., Koudstaal PJ., van der Kuip D., de Ridder MAJ., Witteman JCM., Breteler MMB., Van Broeckhoven C., van Duijn CM.
It is unclear how the APOE genotype contributes to the incidence of vascular diseases and dementia. In a population-based sample (n = 6,852) with complete follow-up, APOE was weakly associated with myocardial infarction and not related with stroke. In the absence of epsilon4, the incidence of dementia would be 25.8% lower; in the absence of epsilon2/epsilon3, 2.8% higher. Risk estimates of dementia, specified for age, sex, and APOE, are provided for counseling. APOE is not strongly related to vascular diseases, but contributes substantially to dementia incidence.