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Search results (44)

« Back to Publications

Discovery of Stereoselective Targeted Covalent Inhibitors of the RAB27-Effector Protein–Protein Interaction

De Vita E. et al, (2026), Journal of the American Chemical Society

YdbL directly modulates YdbH-YnbE bridge formation to maintain Escherichia coli outer membrane homeostasis.

De'Ath C. et al, (2026), mBio

Discovery of stereoselective targeted covalent inhibitors of the RAB27-effector protein-protein interaction

De Vita E. et al, (2026)

SpsB is a target of SOS-response inhibitor OXF-077 and regulates quinolone resistance emergence.

Bradbury JD. et al, (2026), Cell Chem Biol

Rational discovery of therapeutic PAK1 allosteric activators.

He Y. et al, (2026), Cell

YdbL directly modulates YdbH-YnbE bridge formation to maintain Escherichia coli outer membrane homeostasis.

De'Ath C. et al, (2026)

Molecular Glue-like Degraders of TEM β-Lactamases by Periplasmic Protease DegP

Taylor E. et al, (2026)

Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation.

Gray JL. et al, (2025)

Development of a fluorescence-based assay for RecBCD activity using functional data analysis and design of experiments.

Winnifrith A. et al, (2025), RSC Chem Biol, 6, 772 - 779

Chemical proteomics identifies signal peptidase IB (SpsB) as a target of the SOS response inhibitor OXF-077 and a regulator of quinolone resistance emergence in Staphylococcus aureus

Bradbury J. et al, (2025)

Live-Cell Chemoproteomic Profiling Identifies the Uncharacterised Protein YbaA as a Direct Target of Ciprofloxacin in Escherichia coli

Seow T. et al, (2025)

Development of an inhibitor of the mutagenic SOS response that suppresses the evolution of quinolone antibiotic resistance.

Bradbury JD. et al, (2024), Chem Sci, 15, 9620 - 9629

Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.

Ritzefeld M. et al, (2024), J Med Chem, 67, 1061 - 1078

Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.

Jamshidiha M. et al, (2022), RSC Med Chem, 13, 150 - 155

Evaluating Hedgehog Acyltransferase Activity and Inhibition Using the Acylation-coupled Lipophilic Induction of Polarization (Acyl-cLIP) Assay.

Andrei SA. et al, (2022), 2374, 13 - 26

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