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Search results (38)

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YdbL directly modulates YdbH-YnbE bridge formation to maintain Escherichia coli outer membrane homeostasis

De'Ath C. et al, (2026)

Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation.

Gray JL. et al, (2025)

Development of a fluorescence-based assay for RecBCD activity using functional data analysis and design of experiments.

Winnifrith A. et al, (2025), RSC Chem Biol, 6, 772 - 779

Chemical proteomics identifies signal peptidase IB (SpsB) as a target of the SOS response inhibitor OXF-077 and a regulator of quinolone resistance emergence in Staphylococcus aureus

Bradbury J. et al, (2025)

Live-Cell Chemoproteomic Profiling Identifies the Uncharacterised Protein YbaA as a Direct Target of Ciprofloxacin in Escherichia coli

Seow T. et al, (2025)

Development of an inhibitor of the mutagenic SOS response that suppresses the evolution of quinolone antibiotic resistance.

Bradbury JD. et al, (2024), Chem Sci, 15, 9620 - 9629

Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.

Ritzefeld M. et al, (2024), J Med Chem, 67, 1061 - 1078

Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.

Jamshidiha M. et al, (2022), RSC Med Chem, 13, 150 - 155

Evaluating Hedgehog Acyltransferase Activity and Inhibition Using the Acylation-coupled Lipophilic Induction of Polarization (Acyl-cLIP) Assay.

Andrei SA. et al, (2022), 2374, 13 - 26

Structure, mechanism, and inhibition of Hedgehog acyltransferase.

Coupland CE. et al, (2021), Mol Cell, 81, 5025 - 5038.e10

Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation.

Kallemeijn WW. et al, (2021), Nat Protoc, 16, 5083 - 5122

Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT).

Lanyon-Hogg T. et al, (2021), Angew Chem Weinheim Bergstr Ger, 133, 13654 - 13659

Photochemical probe identification of a small-molecule inhibitor binding site in Hedgehog acyltransferase (HHAT)

Lanyon-Hogg T. et al, (2021), Angewandte Chemie International Edition

Targeting the bacterial SOS response for new antimicrobial agents: drug targets, molecular mechanisms and inhibitors.

Lanyon-Hogg T., (2021), Future medicinal chemistry, 13, 143 - 155

Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity".

Panyain N. et al, (2020), J Am Chem Soc, 142

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