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DPAG's Dr Jakub Tomek and Professor Blanca Rodriguez's Computational Cardiovascular Science Team have developed a new computer model that recreates the electrical activity of the ventricles in a human heart. In doing so, they have uncovered and resolved theoretical inconsistencies that have been present in almost all models of the heart from the last 25 years and created a new human heart model that could enable more basic, translational and clinical research into a range of heart diseases and potentially accelerate the development of new therapies.
Overcoming the challenges of genome-editing essential genes
Journal article
Teboul L. and Davies B., (2026), STAR Protocols, 7
Integrative proteogenomic analyses identify plasma proteins that impact the risk of ischemic stroke.
Journal article
Belbasis L. et al, (2026), Commun Med (Lond), 6
BODIPY Photocage-Based Injectable Hydrogel for Light-Controlled Nanoparticle Release.
Journal article
Shao B. et al, (2026), Small
Physiologically relevant media are associated with overlapping metabolic responses in primary human hepatocytes and Huh7 cells.
Journal article
Cross E. et al, (2026), Physiol Rep, 14
Evaluating Open-Source Wrist-Worn Accelerometer Models for Sedentary Time Detection Against Thigh-Worn Accelerometer Data
Preprint
Acquah A. et al, (2026)
FNIP1 variants associated with favorable metabolism in 1 million humans
Journal article
EMBERSON J. et al, (2026), Nature
YdbL directly modulates YdbH-YnbE bridge formation to maintain Escherichia coli outer membrane homeostasis.
Journal article
De'Ath C. et al, (2026), mBio
Non-invasive assessment of coronary inflammation improves the diagnostic accuracy of coronary death in post-mortem CT angiography.
Journal article
Xie C. et al, (2026), J Cardiovasc Comput Tomogr
Blood pressure, kidney function and kidney mortality in Mexico: prospective study of 130,000 adults
Journal article
EMBERSON J. et al, (2026), American Journal of Kidney Diseases
Type 2 diabetes genetics in 125,000 admixed adults from Mexico City.
Preprint
Torres JM. et al, (2026)
The blood metabolome of brain health in midlife and influences of genes, microbiome and exposome.
Journal article
Ahmad S. et al, (2026), Nat Aging
Regulatory logic underlying neural crest contributions to the head versus the heart.
Journal article
Gandhi S. et al, (2026), Proc Natl Acad Sci U S A, 123
Contrastive Machine Learning to Quantify Hypertensive Multiorgan Damage and Identify New Disease Phenotypes: A Multinational Multimodal Study.
Journal article
Alkhodari M. et al, (2026), Circulation
Structural, biophysical and cellular assessment of filamin C M82K: A test case for VUS interpretation in cardiomyopathy.
Journal article
Noureddine M. et al, (2026), J Mol Cell Cardiol
Ambient Air Pollution and Hospital Admissions of AECOPD in 10 Regions of China: A Self-Controlled Study Based on a Cohort.
Journal article
Chen L. et al, (2026), Environ Health (Wash), 4, 1176 - 1184
Combined impact of smoking, alcohol and social inequalities on premature mortality in urban India
Journal article
Gajalakshmi V. et al, (2026), Nature Health
Re-evaluating evidence for a 'naming bias' in scientific awards.
Journal article
Masters-Waage TC. et al, (2026), Nat Hum Behav
Digital twin reconstruction of ventricular repolarisation identifies regional causes of T-wave abnormalities in hypertrophic cardiomyopathy
Preprint
Coleman JA. et al, (2026)
Retinal Vascular Caliber: 6 to 12 Months and 15 to 25 Years Following Hypertensive Pregnancy.
Journal article
Cutler HR. et al, (2026), Hypertension
Economic Evaluation of the Use of Artificial Intelligence in Stress Echocardiography: Cost-Consequence and Cost-Effectiveness Analysis.
Journal article
Chauhan AS. et al, (2026), Value Health Reg Issues