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New collaborative research from the Mommersteeg Group and MRC WIMM researchers shows that a protein called Runx1 plays a significant role in the formation of the cardiac scar that forms after the heart is injured, a scar that is known to inhibit heart regeneration. In the zebrafish, a freshwater fish known to be able to fully regenerate its heart after damage, they show that the absence of Runx1 results in enhanced regeneration. This indicates a potential new therapeutic target for heart repair.
Injected extracellular vesicles and other nanoparticles hitchhike on erythrocytes and platelets from circulation towards organ clearance
Journal article
Pavlova S. et al, (2026), Extracellular Vesicle, 7
Repeatability of Rapid Human Cardiac Phosphorus MRSI (31P-MRSI) Using Concentric Ring Trajectory Readouts at 7 T.
Journal article
Mózes FE. et al, (2026), Magn Reson Med, 95, 2508 - 2514
Consortium-Based Patient and Public Involvement and Engagement for Long COVID Research: A Pirit-Focused Impact Evaluation of the PHOSP-COVID Study.
Journal article
Houchen-Wolloff L. et al, (2026), Health Expect, 29
Effects of Empagliflozin on Urine Biomarkers in EMPA-KIDNEY.
Journal article
Malijan GB. et al, (2026), Am J Kidney Dis, 87, 553 - 563.e1
Stroke in China: advances in prevention and management on the path to a healthy China.
Journal article
Wu S. et al, (2026), Lancet Neurol, 25, 379 - 395
Rational discovery of therapeutic PAK1 allosteric activators.
Journal article
He Y. et al, (2026), Cell
Image-guided optimization of regenerative graft attachment to the heart.
Journal article
Feng Z. et al, (2026), Biomaterials, 332
Plasma extracellular vesicle modulate immune cell transcriptional responses following acute myocardial infarction.
Journal article
Timms L. et al, (2026), iScience, 29
Standard and Ultrahigh Resolution Photon-Counting Coronary CTA-Derived FFR Against Invasive FFR Assessment.
Journal article
Portolan L. et al, (2026), JACC Cardiovasc Imaging
Cohort and Data Resource Update: Mexico City Prospective Study
Journal article
EMBERSON J. et al, (2026), BMJ Medicine
Skeletal muscle adaptation to muscle activity and hypoxia: Differential structural and metabolic remodelling.
Journal article
Hauton D. et al, (2026), J Physiol
Short-term effects of temperature on physical activity and sedentary behavior in Chinese adults: An accelerometer-based analysis.
Journal article
Wei L. et al, (2026), Environ Int, 210
The Impact of Polyethylene Glycol Lipid Anchors on the Physicochemical Properties, Protein Corona, Function, and Biodistribution of Lipid Nanoparticles.
Journal article
Lu C-E. et al, (2026), ACS Nano
A functional overlap between actively transcribed genes and chromatin insulator elements.
Journal article
Cornell LJ. et al, (2026), EMBO J
YdbL directly modulates YdbH-YnbE bridge formation to maintain Escherichia coli outer membrane homeostasis.
Preprint
De'Ath C. et al, (2026)
Dopamine release from Parkinson’s patient-derived neurons is disrupted due to impaired synaptic vesicle loading
Preprint
Cramb KML. et al, (2026)
Electromechanical modelling and simulation of human-induced pluripotent stem cell-derived cardiomyocytes predict drug-induced contractility effects.
Journal article
Folkmanaite M. et al, (2026), J Physiol
Sleep and circadian health in the UK Biobank: Report on the 2023 sleep questionnaire enhancement.
Journal article
Tse KYK. et al, (2026), Sleep