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DPAG's Dr Jakub Tomek and Professor Blanca Rodriguez's Computational Cardiovascular Science Team have developed a new computer model that recreates the electrical activity of the ventricles in a human heart. In doing so, they have uncovered and resolved theoretical inconsistencies that have been present in almost all models of the heart from the last 25 years and created a new human heart model that could enable more basic, translational and clinical research into a range of heart diseases and potentially accelerate the development of new therapies.

Elucidating the mechanisms driving epicardial quiescence to reveal novel targets for cardiac regeneration

Understanding the pathological role of neuropeptide Y in myocardial ischemia-reperfusion

Investigation of a novel player in lymphatic valve development and lymphoedema

Investigation of ADPRHL1 (ARH2), a disease modifier in hypertrophic cardiomyopathy

Variant-specific alterations of myocardial metabolism in patient-derived iPSC-cardiomyocyte models of hypertrophic cardiomyopathy

Mechanism of action of a novel HD2 mutation

High throughput GPCR characterisation utilising Presto-Tango

Implementing transportable hyperpolarized Xenon to expand cardiac-pulmonary functional imaging research.

Investigating a novel gene in endothelial resistance

Dissecting the aetiology of sarcomere-negative hypertrophic cardiomyopathy using convolutional neural network analysis

Development of a human vascularised cardiac organoid system for modelling cell-cell interactions and target discovery in heart disease

Manipulating local phosphodiesterase activity to improve cardiac function

Mechanosensitive adaptor proteins in vascular pathology

Effects of paced heart rate on cerebral blood flow velocity and pulsatility

Myocardial inflammation modelling in iPSC-derived human cardiac organoids

Equipment support for BHF Intermediate Fellowship

Matching in vivo to ex vivo human coronary microvascular function

Impact of the sex-dependence of propionate metabolism on the emergence of novel histone modifications

Targeting cardiovascular disease with peptide inhibitors of chemokines

Uncovering novel regulators of angiogenesis

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