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Investigation of a novel player in lymphatic valve development and lymphoedema

  • 1 November 2023 to 1 August 2024
  • Awards: Pump-priming Awards

Primary lymphoedema is a disease caused by abnormalities of the lymphatic system. A common feature of patients with this disease is insufficient lymphatic valve formation or function. An important stimulus for lymphatic valve formation is fluid shear stress due to lymph flow, imposed on and sensed by lymphatic endothelial cells. In this project, we will investigate the role of a novel player in lymphatic valve formation and its connection to lymphoedema.

Confocal imaging of lymphatic valves in murine mesentery arteries

Image: Confocal imaging of lymphatic valves in murine mesentery arteries