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New collaborative research from the Mommersteeg Group and MRC WIMM researchers shows that a protein called Runx1 plays a significant role in the formation of the cardiac scar that forms after the heart is injured, a scar that is known to inhibit heart regeneration. In the zebrafish, a freshwater fish known to be able to fully regenerate its heart after damage, they show that the absence of Runx1 results in enhanced regeneration. This indicates a potential new therapeutic target for heart repair.
Manhattan++
GWAS, Manhattan plot, meta-analysis, R, software
IDRM Microscopy Oxford-ZEISS Centre of Excellence in Biomedical Imaging
Fluorescent microscopy, slide scanner, high resolution, confocal, light sheet
Flow Cytometry Facility at CHG
Multi-channel FACS, Immune phenotyping, Cardiac cell Sorting, Flowjo analysis, FACS panel design
Biobank Accelerometer Analysis Tool
Physical activity, sleep, step counts, fitness trackers, machine learning
CalTrack
Calcium signalling Calcium quantification Live/fluorescent microscopy MatLab
QuantStudio™ 7 Flex Real-Time PCR System
Genotyping & Genomic Profiling, Real Time PCR, Real Time PCR-Based Gene Expression Profiling
Organ bath
Organ bath Vasomotor Powerlab
UK Biobank (UKB) Research Analysis Platform (RAP)
UK Biobank Research Analysis Platform Multi-omics Cloud computing Big Data
High Resolution Episcopic Microscope
High resolution episcopic microscopy 3D imaging
Fast Protein Liquid Chromatography
Protein purification Size exclusion, ion exchange HisTag chromatography Automatic 12mm tube fractionation 3 buffer channels Direct sample loading
Oroboros O2k FluoRespirometer
Mitochondria Respiration Oxygen consumption Electron transport chain Oxygen electrode