Alice Neal
Postdoctoral Research Scientist
My research focuses on the signalling and transcriptional pathways regulating arteriovenous specification and differentiation in the early embryo.
Although it has been hypothesized that endothelial cells are venous by default while arterial identity is acquired, growing evidence indicates that venous endothelial cell identity is instead dependent upon dynamic gene regulation. My recent research identified multiple vein-specific gene enhancers, and elucidated a BMP-SMAD1/5:SMAD4 regulatory pathway governing early vein specification.
I am currently funded as part of the De Val lab British Heart Foundation Senior Fellowship.
Recent publications
Finding and Verifying Enhancers for Endothelial-Expressed Genes.
Journal article
Neal A. et al, (2022), Methods Mol Biol, 2441, 351 - 368
ETS factors are required but not sufficient for specific patterns of enhancer activity in different endothelial subtypes.
Journal article
Neal A. et al, (2021), Dev Biol, 473, 1 - 14
Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart
Journal article
PAYNE S. et al, (2019), Nature Communications
Venous Identity Requires BMP Signalling Through ALK3
Journal article
NEAL A. et al, (2018), Nature Communications
Endothelial-Specific Cre Mouse Models: Is Your Cre CREdibile?
Journal article
DE VAL SJ. et al, (2018), Arteriosclerosis, Thrombosis, and Vascular Biology