Websites
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British Heart Foundation
Funding body
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Oxford Heart Vessels and Fat (ox-HVF) cohort
Prospective translational programme
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Cardiovascular Research
Journal
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Reuters video on FAI technology
Press
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British Atherosclerosis Society
National Society
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The Lancet 2024
Video
Charalambos Antoniades
British Heart Foundation Chair of Cardiovascular Medicine
- Director, Acute Multidisciplinary Imaging and Interventional Centre (AMIIC)
- Deputy Head, Division of Cardiovascular Medicine
- Professor of Cardiovascular Medicine
- Honorary Consultant Cardiologist
- Chair of the British Atherosclerosis Society
Crosstalk between adipose tissue and the cardiovascular system: From target discovery to advanced imaging and risk prediction
Adipose tissue is now considered to be a “biochemical factory” in the human body, producing a wide range of bioactive molecules, such as adipokines. These molecules exert local autocrine effects, but they also have paracrine and endocrine properties, and may play a critical role in the regulation of redox state and signalling in various tissues, such as the vascular wall and myocardium. Our group studies the mechanisms by which different adipose tissue depots in the human body affect vascular and myocardial redox state in atherosclerosis. We also search for novel therapeutic strategies targeting vascular and myocardial redox signalling directly or through changes in the crosstalk between adipose tissue and cardiovascular system.
Our group undertakes translational research, moving from bench to bedside and vice versa. We use various clinical research tools, such as non-invasive imaging and others, for the evaluation of vascular / myocardial function. This includes studies on human tissues; we have developed a number of ex vivo models of human tissue (vessels, myocardium and adipose tissue) for translational research, which are complemented by tissue and cell culture techniques. We have also established a large bioresource of human vascular, myocardial and adipose tissue in collaboration with other academic institutions across the world (The Oxford Heart Vessels & Fat (ox-HVF) cohort) and this is currently being used to support hypothesis driven research in the field of vascular and myocardial redox state regulation.
In our lab state-of-the-art techniques are used to visualise and quantify vascular and myocardial free radical production.
Using genetic tools to identify patients with pre-specified genetic traits, enables us to apply a “recruit-by-genotype” approach to address biological questions related to the cross-talk between adipose tissue and vascular/myocardial redox signalling in human cardiovascular disease.
We are also using state-of-the-art non-invasive imaging techniques (advanced ultrasound and CT imaging techniques) to study the structure and function of the cardiovascular system and explore its interactions with the adipose tissue. This programme of work led to the recent discovery of the "inside-to-outside" signals from the human cardiovascular system to the adipose tissue, and allowed the development of new clinical applications of cardiovascular imaging.
Since 2015, the group runs the Oxford Cardiovascular Computed Tomography programme, in partnership with the Manor Hospital, supporting the use of state-of-the-art cardiovascular CT imaging by groups within the University of Oxford. The group is using artificial intellience and machine learning approaches to analyse radiotranscriptomic signatures that lead to the develpment of new imaging biomarkers. A recent example is that of the develpment of Fat Attenuation Index (FAI), a new biomarker that detects inflammation in the human coronary arteries by analysing the changes of weighed CT attenuation of perivascular adipose tissue (Science Transl Med 2017). FAI has striking predictive value for cardiac mortality and acute coronary events, as demonstrated in a large prospective clinical study (CRISP-CT) organised together with Erlangen University (Germany) and Cleveland Clinic (USA) (Lancet 2018).
Since 2015, the group runs the Oxford Academic cardiovascular Computed Tomography (OXACCT) programme, in partnership with the Manor Hospital, supporting the use of state-of-the-art cardiovascular CT imaging by groups within the University of Oxford. Within the group, we run the OXACCT Core Lab, peforming advanced analysis of cardiovascular CT images with specific focus on analysis of coronary plaques and perivascular adipose tissue.
Our group also organises small-scale randomised clinical trials that include extensive cardiovascular phenotyping, testing the effects of treatments (statins, folates etc) on the biology of the human vascular wall, myocardium and adipose tissue.
Key publications
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Journal article
Chan K. et al, (2024), Lancet
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Journal article
Antoniades C. et al, (2023), Eur Heart J
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Role of Human Epicardial Adipose Tissue-Derived miR-92a-3p in Myocardial Redox State
Journal article
BADI I., (2023), Journal of the American College of Cardiology
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Journal article
Kotanidis CP. et al, (2022), Lancet Digit Health, 4, e705 - e716
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Journal article
AKOUMIANAKIS I. et al, (2022), Nature Reviews Cardiology
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Journal article
Antoniades C. et al, (2023), Eur Heart J
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Journal article
Oikonomou EK. et al, (2021), Cardiovasc Res
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Journal article
Kondo H. et al, (2021), Eur Heart J
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Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients with Cardiovascular Disease
Journal article
AKAWI N. et al, (2021), Journal of the American College of Cardiology
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Journal article
AKOUMIANAKIS I. et al, (2020), Science Translational Medicine
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¬Perivascular Fat Attenuation Index Stratifies Cardiac Risk Associated With High-Risk Plaques in the CRISP-CT Study
Journal article
Oikonomou E. et al, (2020), Journal of the American College of Cardiology
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Artificial Intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease
Journal article
OIKONOMOU E. and ANTONIADES C., (2020), Cardiovascular Research
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Journal article
AKOUMIANAKIS I. et al, (2019), Science Translational Medicine
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Journal article
Meakin PJ. et al, (2020), J Clin Invest
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Journal article
OIKONOMOU E. et al, (2019), European Heart Journal
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New method for non-invasive detection of coronary inflammation using computed tomography angiography predicts residual cardiovascular risk
Journal article
OIKONOMOU E. et al, (2018), Lancet
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Journal article
Elnabawi YA. et al, (2019), JAMA Cardiol
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Journal article
Antoniades C. et al, (2020), Eur Heart J, 41, 748 - 758
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Journal article
Antonopoulos AA. et al, (2017), Science Translational Medicine
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Journal article
Antonopoulos ASA. et al, (2016), Circulation Research
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Journal article
Antonopoulos AS. et al, (2015), Diabetes, 64, 2207 - 2219
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Journal article
Margaritis M. et al, (2013), Circulation, 127, 2209 - 2221
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Journal article
Antoniades C. et al, (2012), J Am Coll Cardiol, 59, 60 - 70
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Journal article
Antoniades C. et al, (2011), Circulation, 124, 1860 - 1870
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Antoniades C. et al, (2011), Circulation, 124, 335 - 345
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Antoniades C. et al, (2010), Circulation, 122, S66 - S73
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Journal article
Antoniades C. et al, (2009), J Am Coll Cardiol, 54, 669 - 677
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Antoniades C. et al, (2007), Circulation, 116, 2851 - 2859
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Shirodaria C. et al, (2007), Circulation, 115, 2262 - 2270
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Journal article
Antoniades C. et al, (2006), J Am Coll Cardiol, 47, 1959 - 1966
Recent publications
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Journal article
Tsiachristas A. et al, (2024), Eur Heart J Qual Care Clin Outcomes
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Journal article
Koskinas KC. et al, (2024), Eur J Prev Cardiol
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Journal article
Koskinas KC. et al, (2024), Eur Heart J
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Journal article
Lüscher TF. et al, (2024), Eur Heart J
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Journal article
Chan K. et al, (2024), Lancet
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Journal article
Kluener L. et al, (2024), Atherosclerosis, 117580 - 117580
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Journal article
Kotronias RA. et al, (2024), Eur Heart J Cardiovasc Imaging
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Journal article
Polkinghorne MD. et al, (2023), Annu Rev Physiol
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Journal article
Manfield J. et al, (2023), Neuromodulation
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Journal article
Nakahara T. et al, (2023), Radiology, 308
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Journal article
Manfield J. et al, (2023), Brain Stimul, 16, 1276 - 1277
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Journal article
Antoniades C. et al, (2023), Eur Heart J
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Role of Human Epicardial Adipose Tissue-Derived miR-92a-3p in Myocardial Redox State
Journal article
BADI I., (2023), Journal of the American College of Cardiology
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Journal article
Hundertmark MJ. et al, (2023), Circulation, 147, 1654 - 1669
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Journal article
Vavere AL. et al, (2023), J Am Heart Assoc
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Journal article
Antoniades C. et al, (2023), Eur Heart J
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Genetic variability of lipoprotein(a) controls vascular inflammation/redox signalling and predicts adverse cardiovascular outcomes in coronary artery disease N.
Journal article
Polkinghorne MD. et al, (2023), EUROPEAN HEART JOURNAL, 44
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Human epicardial adipose tissue-secreted miR-92a-3p regulates myocardial redox state via paracrine signalling: implications for cardiovascular clinical outcomes
Journal article
Badi I. et al, (2023), EUROPEAN HEART JOURNAL, 44
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Deep-Learning for Epicardial Adipose Tissue Assessment with Computed Tomography: Implications for Cardiovascular Risk Prediction
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West H. et al, (2022), JACC: Cardiovascular Imaging
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Journal article
Figtree GA. et al, (2022), Circulation, 146, 1712 - 1727