Contact information
Websites
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British Heart Foundation
Funding body
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Oxford Heart Vessels and Fat (ox-HVF) cohort
Prospective translational programme
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Cardiovascular Research
Journal
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Reuters video on FAI technology
Press
Charalambos Antoniades
Professor of Cardiovascular Medicine
- Director, Acute Vascular Imaging Centre
- Deputy Head, Division of Cardiovascular Medicine
- British Heart Foundation Senior Clinical Fellow
- Honorary Consultant Cardiologist
Crosstalk between adipose tissue and vascular/myocardial redox state in humans: Pharmacological interventions
Adipose tissue is now considered to be a “biochemical factory” in the human body, producing a wide range of bioactive molecules, such as adipokines. These molecules exert local autocrine effects, but they also have paracrine and endocrine properties, and may play a critical role in the regulation of redox state and signalling in various tissues, such as the vascular wall and myocardium. Our group studies the mechanisms by which different adipose tissue depots in the human body affect vascular and myocardial redox state in atherosclerosis. We also search for novel therapeutic strategies targeting vascular and myocardial redox signalling directly or through changes in the crosstalk between adipose tissue and cardiovascular system.
Our group undertakes translational research, moving from bench to bedside and vice versa. We use various clinical research tools, such as non-invasive imaging and others, for the evaluation of vascular / myocardial function. This includes studies on human tissues; we have developed a number of ex vivo models of human tissue (vessels, myocardium and adipose tissue) for translational research, which are complemented by tissue and cell culture techniques. We have also established a large bioresource of human vascular, myocardial and adipose tissue in collaboration with other academic institutions across the world (The Oxford Heart Vessels & Fat (ox-HVF) cohort) and this is currently being used to support hypothesis driven research in the field of vascular and myocardial redox state regulation.
In our lab state-of-the-art techniques are used to visualise and quantify vascular and myocardial free radical production.
Using genetic tools to identify patients with pre-specified genetic traits, enables us to apply a “recruit-by-genotype” approach to address biological questions related to the cross-talk between adipose tissue and vascular/myocardial redox signalling in human cardiovascular disease.
We are also using state-of-the-art non-invasive imaging techniques (advanced ultrasound and CT imaging techniques) to study the structure and function of the cardiovascular system and explore its interactions with the adipose tissue. This programme of work led to the recent discovery of the "inside-to-outside" signals from the human cardiovascular system to the adipose tissue, and allowed the development of new clinical applications of cardiovascular imaging.
Since 2015, the group runs the Oxford Cardiovascular Computed Tomography programme, in partnership with the Manor Hospital, supporting the use of state-of-the-art cardiovascular CT imaging by groups within the University of Oxford. The group is using artificial intellience and machine learning approaches to analyse radiotranscriptomic signatures that lead to the develpment of new imaging biomarkers. A recent example is that of the develpment of Fat Attenuation Index (FAI), a new biomarker that detects inflammation in the human coronary arteries by analysing the changes of weighed CT attenuation of perivascular adipose tissue (Science Transl Med 2017). FAI has striking predictive value for cardiac mortality and acute coronary events, as demonstrated in a large prospective clinical study (CRISP-CT) organised together with Erlangen University (Germany) and Cleveland Clinic (USA) (Lancet 2018).
Since 2015, the group runs the Oxford Academic cardiovascular Computed Tomography (OXACCT) programme, in partnership with the Manor Hospital, supporting the use of state-of-the-art cardiovascular CT imaging by groups within the University of Oxford. Within the group, we run the OXACCT Core Lab, peforming advanced analysis of cardiovascular CT images with specific focus on analysis of coronary plaques and perivascular adipose tissue.
Our group also organises small-scale randomised clinical trials that include extensive cardiovascular phenotyping, testing the effects of treatments (statins, folates etc) on the biology of the human vascular wall, myocardium and adipose tissue.
Key publications
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Journal article
AKOUMIANAKIS I. et al, (2020), Science Translational Medicine
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¬Perivascular Fat Attenuation Index Stratifies Cardiac Risk Associated With High-Risk Plaques in the CRISP-CT Study
Journal article
Oikonomou E. et al, (2020), Journal of the American College of Cardiology
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Artificial Intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease
Journal article
OIKONOMOU E. and ANTONIADES C., (2020), Cardiovascular Research
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Journal article
AKOUMIANAKIS I. et al, (2019), Science Translational Medicine
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Journal article
Meakin PJ. et al, (2020), J Clin Invest
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Journal article
OIKONOMOU E. et al, (2019), European Heart Journal
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New method for non-invasive detection of coronary inflammation using computed tomography angiography predicts residual cardiovascular risk
Journal article
OIKONOMOU E. et al, (2018), Lancet
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Journal article
Elnabawi YA. et al, (2019), JAMA Cardiol
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Journal article
Antoniades C. et al, (2020), Eur Heart J, 41, 748 - 758
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Journal article
Antonopoulos AA. et al, (2017), Science Translational Medicine
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Journal article
Antonopoulos ASA. et al, (2016), Circulation Research
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Journal article
Antonopoulos AS. et al, (2015), Diabetes, 64, 2207 - 2219
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Journal article
Margaritis M. et al, (2013), Circulation, 127, 2209 - 2221
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Journal article
Antoniades C. et al, (2012), J Am Coll Cardiol, 59, 60 - 70
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Journal article
Antoniades C. et al, (2011), Circulation, 124, 1860 - 1870
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Journal article
Antoniades C. et al, (2011), Circulation, 124, 335 - 345
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Journal article
Antoniades C. et al, (2010), Circulation, 122, S66 - S73
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Journal article
Antoniades C. et al, (2009), J Am Coll Cardiol, 54, 669 - 677
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Journal article
Antoniades C. et al, (2007), Circulation, 116, 2851 - 2859
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Journal article
Shirodaria C. et al, (2007), Circulation, 115, 2262 - 2270
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Journal article
Antoniades C. et al, (2006), J Am Coll Cardiol, 47, 1959 - 1966
Recent publications
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Journal article
Sage AP. and Antoniades C., (2021), Br J Pharmacol
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Journal article
Klüner LV. et al, (2021), Radiology: Cardiothoracic Imaging, 3, e200563 - e200563
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Journal article
Toutouzas K. et al, (2021), J Nucl Cardiol
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Journal article
Badi I. and Antoniades C., (2021), Circulation, 143, 160 - 162
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Journal article
SHANMUGANATHAN M., (2021), EClinicalMedicine
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Journal article
Antonopoulos AS. and Antoniades C., (2021), Eur J Nucl Med Mol Imaging
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Journal article
Antoniades C. et al, (2021), Eur Heart J
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Journal article
Brown SK. and Antoniades C., (2020), Cardiovasc Res, 116, e186 - e189
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Journal article
Sheikh AM. et al, (2020), Cardiovasc Res, 116, e165 - e168
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Journal article
Elliott P. et al, (2020), Cardiovasc Res
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Journal article
Abdelrahman KM. et al, (2020), J Am Coll Cardiol, 76, 1226 - 1243
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Selfies in Cardiovascular Medicine: Welcome to a New Era of Medical Diagnostics
Journal article
Kotanidis C. and ANTONIADES C., (2020), European Heart Journal
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Journal article
Oikonomou E. et al, (2020), Atherosclerosis, 309, 16 - 26
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¬Perivascular Fat Attenuation Index Stratifies Cardiac Risk Associated With High-Risk Plaques in the CRISP-CT Study
Journal article
Oikonomou E. et al, (2020), Journal of the American College of Cardiology
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Journal article
West HW. and Antoniades C., (2020), Antioxid Redox Signal
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Journal article
Antonopoulos AS. et al, (2020), J Thorac Cardiovasc Surg
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Journal article
Nikolaidou C. et al, (2020), Eur Heart J Cardiovasc Imaging
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Journal article
Meakin PJ. et al, (2020), J Clin Invest
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Journal article
AKOUMIANAKIS I. et al, (2020), Science Translational Medicine
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Chapter
Kotanidis C. and ANTONIADES C., (2020), Epicardial Adipose Tissue From Cell to Clinic, 91 - 115
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Journal article
West HW. and Antoniades C., (2020), AIDS (London, England), 34, 489 - 490
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Artificial Intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease
Journal article
OIKONOMOU E. and ANTONIADES C., (2020), Cardiovascular Research
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Journal article
Antoniades C. et al, (2020), Eur Heart J, 41, 748 - 758
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Journal article
Tousoulis D. et al, (2020), Eur J Prev Cardiol
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Journal article
Elnabawi YA. et al, (2020), JAMA Cardiol
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Journal article
Antonopoulos AS. et al, (2020), European Journal of Clinical Investigation
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Journal article
Antoniades C. and Condorelli G., (2019), Cardiovasc Res, 115, e164 - e165
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Journal article
Zacharia E. et al, (2019), J Mol Cell Cardiol
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Conference paper
Akoumianakis I. et al, (2019), European Heart Journal, 40, 1660 - 1660
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Journal article
Gaudino M. et al, (2019), Circulation, 140, 1273 - 1284
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Journal article
Douglas G. et al, (2019), Cardiovasc Res
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Journal article
AKOUMIANAKIS I. et al, (2019), Science Translational Medicine
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Journal article
OIKONOMOU E. et al, (2019), European Heart Journal
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Computed Tomography: Assessment of Coronary Inflammation and Other Plaque Features
Journal article
OIKONOMOU E. et al, (2019), Arteriosclerosis, Thrombosis, and Vascular Biology
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Journal article
Antonopoulos AS. et al, (2019), J Thorac Cardiovasc Surg
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Journal article
Spadaccio C. et al, (2019), Cardiovasc Res
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Journal article
Elnabawi YA. et al, (2019), JAMA Cardiol
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Journal article
Oikonomou EK. and Antoniades C., (2019), Lancet, 393, 2199 - 2200
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Journal article
Kotanidis CP. and Antoniades C., (2019), European heart journal
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Journal article
Antoniades C. et al, (2019), J Cardiovasc Comput Tomogr
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Journal article
Antoniades C. and Harrison DG., (2019), Cardiovascular research, 115, e44 - e45
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Journal article
Antoniades C. and Shirodaria C., (2019), JACC Cardiovasc Imaging
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Journal article
Rodríguez-Granillo GA. et al, (2019), Journal of thoracic imaging, 34, 33 - 40
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Journal article
Patel VH. et al, (2018), Clin Sci (Lond), 132, 2547 - 2564
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Journal article
Rayner JJ. et al, (2018), Int J Obes (Lond)
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Journal article
OIKONOMOU E. and Antoniades C., (2018), Nature Reviews Cardiology
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Journal article
Guzik TJ. et al, (2018), Cardiovascular research, 114, 1565 - 1568
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New method for non-invasive detection of coronary inflammation using computed tomography angiography predicts residual cardiovascular risk
Journal article
OIKONOMOU E. et al, (2018), Lancet
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Journal article
Antonopoulos AS. and Antoniades C., (2018), Circulation. Cardiovascular imaging, 11, e008083 - e008083
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Journal article
Pinho-Gomes A-C. et al, (2018), Eur J Cardiothorac Surg, 54, 221 - 228
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Journal article
Oikonomou EK. et al, (2018), Oncologist, 23, 965 - 973
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Journal article
Gaudino M. et al, (2018), Journal of the American Heart Association, 7, e009934 - e009934
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Journal article
Antonopoulos AS. and Antoniades C., (2018), Hellenic J Cardiol, 59, 207 - 208
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Journal article
Antonopoulos AS. and Antoniades C., (2018), J Am Coll Cardiol, 71, 2708 - 2709
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Journal article
Tarun A. and Antoniades C., (2018), Cardiovascular research, 114, 928 - 930
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Perivascular adipose tissue and coronary atherosclerosis
Journal article
MANCIO J. et al, (2018), Heart
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Perivascular adipose tissue and coronary atherosclerosis
Journal article
OIKONOMOU E. et al, (2018), Heart
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Journal article
Lazaros G. et al, (2018), Current cardiology reports, 20, 40 - 40
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Journal article
Cerrato R. et al, (2018), Scandinavian cardiovascular journal : SCJ, 1 - 7
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Journal article
Kotanidis CP. et al, (2018), JACC. Cardiovascular imaging
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Journal article
Navaratnarajah M. et al, (2018), J Cardiothorac Surg, 13
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Journal article
Guzik T., (2018), Cardiovascular research, 114, e10 - e10
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Journal article
Toutouzas K. et al, (2018), J Clin Lipidol, 12, 33 - 43
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Journal article
Antoniades C. et al, (2017), Cardiovascular research, 114, e9 - e9
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Journal article
Akoumianakis I. and Antoniades C., (2017), Antioxidants & redox signaling
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Journal article
Antoniades C., (2017), European heart journal, 38, 2795 - 2796
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Journal article
Gaudino M. et al, (2017), Circulation, 136, 1749 - 1764
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Journal article
Sanna F. et al, (2017), Current Pharmaceutical Design, 23
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Journal article
Margaritis M. et al, (2017), Current Pharmaceutical Design, 23
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Journal article
Akoumianakis I. et al, (2017), Korean circulation journal, 47, 670 - 685
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Journal article
Antonopoulos AA. et al, (2017), Science Translational Medicine
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Journal article
Akoumianakis I. and Antoniades C., (2017), Vascul Pharmacol
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Journal article
Antoniades C., (2017), Cardiovascular research, 113, 997 - 998
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Immunometabolic regulation of vascular redox state: the role of adipose tissue
Journal article
OIKONOMOU E. and antoniades CA., (2017), Antioxidants and Redox Signaling
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Journal article
Lee R. et al, (2017), Clin Proteomics, 14, 22 - 22
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The interplay between adipose tissue and the cardiovascular system: is fat always bad?
Journal article
Akoumianakis I. and Antoniades CA., (2017), Cardiovascular Research
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Journal article
Taggart DP. et al, (2017), Eur J Cardiothorac Surg, 51, 952 - 958
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Journal article
Margaritis M. et al, (2017), European Heart Journal
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Journal article
Lee R. et al, (2017), European Journal of Vascular and Endovascular Surgery
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Journal article
Antonopoulos AS. and Antoniades C., (2017), J Physiol
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Journal article
Turnbull CD. et al, (2017), Eur Respir J, 49
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Journal article
Lazaros G. et al, (2017), Eur J Clin Invest, 47, 129 - 136
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Chapter
Antonopoulos AS. et al, (2017), Coronary Artery Disease: From Biology to Clinical Practice, 121 - 126
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Chapter
Falconer D. et al, (2017), Coronary Artery Disease: From Biology to Clinical Practice, 301 - 317
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Journal article
Akoumianakis I. et al, (2016), Br J Pharmacol
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Journal article
Woodward LC. et al, (2016), Ann Thorac Surg, 102, 1736 - 1746
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From the BMI paradox to the obesity paradox: the obesity-mortality association in coronary heart disease.
Journal article
Antonopoulos AS. et al, (2016), Obesity reviews : an official journal of the International Association for the Study of Obesity, 17, 989 - 1000
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Unravelling the adiponectin paradox: novel roles of adiponectin in the regulation of cardiovascular disease.
Journal article
Woodward L. et al, (2016), British journal of pharmacology
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Conference paper
Turnbull C. et al, (2016), The European Respiratory Journal
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Conference paper
Turnbull C. et al, (2016), European Respiratory Society Congress London 2016
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Journal article
Levelt E. et al, (2016), Journal of the American College of Cardiology, 68, 53 - 63
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Journal article
Akoumianakis I. and Antoniades C., (2016), Cardiovascular research, 111, 10 - 12
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Journal article
Antoniades C. and Vilahur G., (2016), Cardiovascular research, 111, 120 - 122
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Ectopic and visceral fat deposition in lean and obese type 2 diabetes patients
Journal article
Levelt E. et al, (2016), Journal of the American College of Cardiology
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Journal article
Fabritz L. et al, (2016), Nat Rev Cardiol, 13, 230 - 237
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Journal article
Antoniades C. et al, (2016), Eur Respir J, 47, 1014 - 1015
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Journal article
Antonopoulos ASA. et al, (2016), Circulation Research
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Journal article
Clunie-O'Connor C. et al, (2015), Curr Protoc Stem Cell Biol, 35, 2C.5.1 - 2C.512
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Journal article
Bang C. et al, (2015), Eur J Heart Fail, 17, 1091 - 1103
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Journal article
Antonopoulos AS. et al, (2015), Int J Cardiol, 197, 125 - 127