Contact information
damian.tyler@dpag.ox.ac.uk
damian.tyler@cardiov.ox.ac.uk
01865 234586
01865 282252
Research groups
Colleges
Websites
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BHF
British Heart Foundation
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OCMR
Oxford Centre for Clinical Magnetic Resonance Research
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Oxford - BHF 4-year Graduate Programme
Oxford - BHF 4-year Graduate Training Scheme
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Oxford DTC
The University of Oxford Doctoral Training Centre
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Interdisciplinary Biosciences DTP
Oxford Interdisciplinary Biosciences Doctoral Training Programme
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Oxford-Nottingham Biomedical Imaging CDT
Oxford-Nottingham Biomedical Imaging Centre for Doctoral Training
Damian Tyler
Professor of Physiological Metabolism
I am currently a British Heart Foundation Senior Research Fellow and a Tutorial Fellow in Medicine at Somerville College.
I have been based in Oxford since 2001 and have 15 years experience in the development and application of Magnetic Resonance Imaging and Spectroscopy (MRI/MRS). I gained my MSci in Medical Physics in 1998 and my doctorate in 2001, both from the University of Nottingham. I am an associate member of the Cardiac Metabolism Research Group (CMRG) and leads the Oxford Metabolic Imaging Group.
My research in Oxford has been based on the study of cardiac structure, function and metabolism in normal and diseased hearts using MRI/MRS. This has included developing techniques using high spatial and temporal resolution CINE imaging to assess heart function and localized phosphorus and carbon spectroscopy to monitor and investigate abnormalities of metabolism. I have recently been awarded a British Heart Foundation Senior Research Fellowship to further develop the technique of Dynamic Nuclear Polarization (DNP) for application to the study of cardiac metabolism in the human heart. A fundamental limitation of magnetic resonance is its low sensitivity, but the recently developed technique of DNP provides a practical method to gain up to 10,000-fold increases in sensitivity in molecules with an in vivo stability of approximately one minute. This has enabled visualization of 13C-labelled cellular metabolites in vivo and, more importantly, their enzymatic transformation into other species. This is an important development that could revolutionize spectroscopy using MR.
Key publications
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The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study.
Journal article
Schroeder MA. et al, (2012), Circ Cardiovasc Imaging, 5, 201 - 209
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Hyperpolarized magnetic resonance: a novel technique for the in vivo assessment of cardiovascular disease.
Journal article
Schroeder MA. et al, (2011), Circulation, 124, 1580 - 1594
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Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study.
Journal article
Atherton HJ. et al, (2011), Circulation, 123, 2552 - 2561
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Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy.
Journal article
Schroeder MA. et al, (2009), FASEB J, 23, 2529 - 2538
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In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance.
Journal article
Schroeder MA. et al, (2008), Proc Natl Acad Sci U S A, 105, 12051 - 12056
Recent publications
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Hyperpolarized carbon-13 MRI: clinical applications and future directions in oncology
Journal article
Deen SS. et al, (2023), Radiology: Imaging Cancer
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Compartment‐based Reconstruction of 3D Acquisition‐Weighted
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P Cardiac MRSI at 7T ‐ a Reproducibility Study
Journal article
Tyler A. et al, (2023), NMR in Biomedicine
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RF coil design for accurate parallel imaging on 13C MRSI using 23Na sensitivity profiles
Journal article
Sanchez-Heredia JD. et al, (2022), Magnetic Resonance in Medicine
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Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH
Journal article
Abigail W. et al, (2021), Cardiovascular Research
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Activation of HIF1α Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart.
Journal article
da Luz Sousa Fialho M. et al, (2021), Diabetes