Gil McVean
FRS FMedSci
Director, Big Data Institute; Professor of Statistical Genetics, Nuffield Department of Medicine
- Head of Bioinformatics and Statistical Genetics
- University Lecturer in Mathematical Genetics
- Group Head / PI and Unit Director,
My research covers several areas in the analysis of genetic variation, combining the development of methods for analysing high throughput sequencing data, theoretical work and empirical analysis. Of particular interest are: the analysis of recombination from population genetic data, dissecting signals of disease association within the HLA, methods for inferring genealogical history from DNA sequence data and de novo sequence assemblyfor the discovery of genetic variation. I am a member of the Mathematical Genetics Group in the Department of Statistics and Acting Director of the new Oxford Big Data Institute.
Recent publications
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Genetic mapping across autoimmune diseases reveals shared associations and mechanisms.
Journal article
Lincoln MR. et al, (2024), Nat Genet, 56, 838 - 845
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High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response.
Journal article
Mentzer AJ. et al, (2024), Nat Med, 30, 1384 - 1394
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A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy.
Journal article
Chong AY. et al, (2024), Am J Hum Genet, 111, 295 - 308
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A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release.
Journal article
Thompson DJ. et al, (2024), PLoS One, 19
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Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk.
Journal article
Jiang X. et al, (2023), Nat Genet