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James Holt-Martyn

BHF CRE Cardiovascular Medicinal Chemistry Graduate Student

Project Title: Molecular Interactions with the Prolyl Hydroxylase Domain Enzymes for Stabilizing and Destabilizing the Hypoxia Inducible Factor

Supervisors: Professor Chris Schofield, Professor Chris Pugh, Professor Sir Peter Radcliffe

Biography

James was awarded a Master of Chemistry and Bachelor of Science in Medicinal Chemistry in 2012 from the University of Leeds (1st Class Hons).

In October 2013, he began the BHF DPhil in Cardiovascular Medicinal Chemistry and is currently working on the two 10 week project rotations.

The first rotation is with Prof Chris Schofield, Prof Chris Pugh and Prof Frances Ashcroft working on potent and selective inhibitors of histone demethylases.

The second rotation is with Dr Angela Russell and Dr Richard Wade-Martins on synthesis of small molecule adjuvants to treat familial hypercholesterolaemia by upregulation of low density lipoprotein receptor expression.

His 3 year DPhil project is with Prof Chris Schofield, Prof Chris Pugh and Prof Sir Peter Ratcliffe designing novel selective prolyl hydroxylase inhibitors for hypoxia inducible factor (HIF) stabilization.

Undergraduate degree:  Master of Chemistry and Bachelor of Science in Medicinal Chemistry in 2012 from the University of Leeds (1st Class Hons).

Studentship dates: 2013 cohort.  October 2013 – September 2017

Thesis submitted January 2018