Dr Kerstin N Timm
Oxford BHF CRE Basic Science Intermediate Transition Fellow
- Start Date: 15/05/2020
- End Date: 14/05/2023
- BHF CRE Mentors: Prof Damian Tyler & Prof Antony Galione
Research project title: Cardioprotection in Doxorubicin-induced Heart Failure
Some chemotherapeutic agents, such as doxorubicin, have severe cardiotoxic side effects, which can lead to congestive heart failure in 5% of patients. There are currently no imaging techniques available to detect patients before the onset of functional decline and there are no specific cardio-protective drugs. My research focuses on both the early detection of cardiotoxicity using the novel metabolic imaging technique, hyperpolarized magnetic resonance imaging (MRI) and the repurposing of existing drugs that target cardiac metabolism as potential cardio-protective therapy.
As the number of cancer survivors increase, so do the unfortunate long-term side effects of chemotherapy. With my research, I hope to uncover imaging biomarkers that can identify early toxic changes to the heart in a preclinical setting. I furthermore hope to test existing drugs as cardioprotective agents in this setting, which could be repurposed in cancer patients to reduce the incidence of chemotherapy-induced heart failure.
I am excited to start my own independent research program as Career Development Fellow at the Department of Pharmacology. I hope to be able to secure an external Intermediate Level Fellowship in the next few years to drive my research in cardio-oncology forward.
Veterinary Medicine (FU Berlin, Germany)
MRes “In vivo imaging in Biology and Medicine” (Cambridge)
Neutrophils incite and macrophages avert electrical storm after myocardial infarction.
Grune J. et al, (2022), Nat Cardiovasc Res, 1, 649 - 664
Cancer Therapy-Induced Cardiotoxicity—A Metabolic Perspective on Pathogenesis, Diagnosis and Therapy
Choksey A. and Timm KN., (2021), International Journal of Molecular Sciences, 23, 441 - 441
L-Carnitine Stimulates In Vivo Carbohydrate Metabolism in the Type 1 Diabetic Heart as Demonstrated by Hyperpolarized MRI.
Savic D. et al, (2021), Metabolites, 11
Metabolic Effects of Doxorubicin on the Rat Liver Assessed With Hyperpolarized MRI and Metabolomics.
Timm KN. et al, (2021), Front Physiol, 12