DPHIL PROJECTS AVAILABLE
Associate Professor of Metabolic Imaging
- Sir Henry Dale Fellow of the Wellcome Trust
Investigation of energy metabolism in human tissues using ultra high field magnetic resonance spectroscopy.
My research focuses on magnetic resonance (MR) metabolic imaging. This involves quantification of energy metabolites and metabolic reaction rates using MR spectroscopy (MRS), to non-invasively detect metabolic impairments and to monitor therapy outcome. My work focuses on method development for the assessment of energy metabolism of human heart, liver and skeletal muscle in disease. This is crucial to understand the impact of systemic and cardiovascular diseases on these systems. A lot of my work examines interventions of increased physical activity to improve oxidative metabolism and exercise tolerance of elderly people and also to manage individual weight in obesity and diabetes.
I mainly use our ultra-high field (7T) MR system, as it provides exceptional signal-to-noise ratio (SNR), in particular for my phosphorus (31P)-MRS experiments. This improvement in SNR allows me to develop methods to acquire high quality spatially resolved data with high temporal resolution. In particular, I have developed the first clinically feasible technique worldwide that allows assessment of stimulated oxidative energy production rate, in only one exercise repetition. As nothing comes for free, 7T brings several challenges, eg field inhomogeneities. Therefore I also develop techniques to overcome these challenges, eg interleaved excitation with narrow-banded, field insensitive excitation pulse for cardiac energetics quantification. I collaborate with several research groups in Oxford interested in non-invasive oxidative metabolism measurements. I am also a former member of the MRS group at the Medical University of Vienna, and thus, have strong ties to research groups in Central Europe, ie Austria, Slovakia and Czech Republic, interested in MRS method development and exercise interventions.
Evaluation of Acute Supplementation With the Ketone Ester (R)-3-Hydroxybutyl-(R)-3-Hydroxybutyrate (deltaG) in Healthy Volunteers by Cardiac and Skeletal Muscle 31P Magnetic Resonance Spectroscopy
Cameron D. et al, (2022), Frontiers in Physiology, 13
2½-minute 3D 7T 31P-MRSI of the human heart using concentric rings (CRT)
Clarke WT. et al, (2021)
Impaired myocardial energetics limits cardiac functional reserve and leads to exercise-induced pulmonary congestion in heart failure with preserved ejection fraction
Burrage M. et al, (2021), EUROPEAN HEART JOURNAL, 42, 734 - 734
Design and rationale of the EMPA-VISION trial: investigating the metabolic effects of empagliflozin in patients with heart failure.
Hundertmark MJ. et al, (2021), ESC Heart Fail, 8, 2580 - 2590
Noninvasive assessment of steatosis and viability of cold-stored human liver grafts by MRI.
Young LAJ. et al, (2021), Magn Reson Med