Wellcome Trust Sir Henry Dale Fellow
During embryonic development, dynamic interplay between cell growth, differentiation and morphogenesis establishes diverse specialized cell types with unique functions. My research aims to understand how these developmental processes specify the array of heterogeneous cell subtypes found within the vertebrate vasculature.
Following a PhD at the University of Bristol studying neovascularization of adult tissues with David Bates, I undertook postdoctoral training with Didier Stainier at the University of California, San Francisco and Max Planck Institute for Heart and Lung Research. Using zebrafish and mouse models, I identified the earliest known transcriptional regulator of endothelial/blood cell differentiation from mesoderm (Reischauer*, Stone* et al., Nature, 2016), and found the mesodermal source of endothelial cells to be a key determinant of their eventual fate (Stone and Stainier, Developmental Cell, 2019).
My group, which is funded by a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society, investigates the impact of lineage history on the terminal fate and function of endothelial cells in blood and lymphatic vessels.
Lupu I-E. et al, (2022)
Stone OA. et al, (2021), Bioessays, 43